CXCR4-directed theranostics in oncology and inflammation

Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experi...

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Detalles Bibliográficos
Autores principales: Kircher, Malte, Herhaus, Peter, Schottelius, Margret, Buck, Andreas K., Werner, Rudolf A., Wester, Hans-Jürgen, Keller, Ulrich, Lapa, Constantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2018
Materias:
Invited Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182637/
https://www.ncbi.nlm.nih.gov/pubmed/30105558
http://dx.doi.org/10.1007/s12149-018-1290-8
Descripción
Sumario:Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experience of targeting CXCR4, using radiolabeled receptor ligands suitable for positron emission tomography (PET) imaging, in both hematologic and solid malignancy as well as in inflammatory conditions. Additionally, CXCR4-directed endoradiotherapy (ERT) as a new treatment option is discussed.

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