CXCR4-directed theranostics in oncology and inflammation

Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experi...

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Autores principales: Kircher, Malte, Herhaus, Peter, Schottelius, Margret, Buck, Andreas K., Werner, Rudolf A., Wester, Hans-Jürgen, Keller, Ulrich, Lapa, Constantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2018
Materias:
Invited Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182637/
https://www.ncbi.nlm.nih.gov/pubmed/30105558
http://dx.doi.org/10.1007/s12149-018-1290-8
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author Kircher, Malte
Herhaus, Peter
Schottelius, Margret
Buck, Andreas K.
Werner, Rudolf A.
Wester, Hans-Jürgen
Keller, Ulrich
Lapa, Constantin
author_facet Kircher, Malte
Herhaus, Peter
Schottelius, Margret
Buck, Andreas K.
Werner, Rudolf A.
Wester, Hans-Jürgen
Keller, Ulrich
Lapa, Constantin
author_sort Kircher, Malte
collection PubMed
description Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experience of targeting CXCR4, using radiolabeled receptor ligands suitable for positron emission tomography (PET) imaging, in both hematologic and solid malignancy as well as in inflammatory conditions. Additionally, CXCR4-directed endoradiotherapy (ERT) as a new treatment option is discussed.
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spelling pubmed-61826372018-10-24 CXCR4-directed theranostics in oncology and inflammation Kircher, Malte Herhaus, Peter Schottelius, Margret Buck, Andreas K. Werner, Rudolf A. Wester, Hans-Jürgen Keller, Ulrich Lapa, Constantin Ann Nucl Med Invited Review Article Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experience of targeting CXCR4, using radiolabeled receptor ligands suitable for positron emission tomography (PET) imaging, in both hematologic and solid malignancy as well as in inflammatory conditions. Additionally, CXCR4-directed endoradiotherapy (ERT) as a new treatment option is discussed. Springer Japan 2018-08-13 2018 /pmc/articles/PMC6182637/ /pubmed/30105558 http://dx.doi.org/10.1007/s12149-018-1290-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Invited Review Article
Kircher, Malte
Herhaus, Peter
Schottelius, Margret
Buck, Andreas K.
Werner, Rudolf A.
Wester, Hans-Jürgen
Keller, Ulrich
Lapa, Constantin
CXCR4-directed theranostics in oncology and inflammation
title CXCR4-directed theranostics in oncology and inflammation
title_full CXCR4-directed theranostics in oncology and inflammation
title_fullStr CXCR4-directed theranostics in oncology and inflammation
title_full_unstemmed CXCR4-directed theranostics in oncology and inflammation
title_short CXCR4-directed theranostics in oncology and inflammation
title_sort cxcr4-directed theranostics in oncology and inflammation
topic Invited Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182637/
https://www.ncbi.nlm.nih.gov/pubmed/30105558
http://dx.doi.org/10.1007/s12149-018-1290-8
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