Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals

The physiologically based pharmacokinetic (PBPK) models allow for predictive assessment of variability in population of interest. One of the future application of PBPK modeling is in the field of precision dosing and personalized medicine. The aim of the study was to develop PBPK model for amitripty...

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Detalles Bibliográficos
Autores principales: Tylutki, Zofia, Mendyk, Aleksander, Polak, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182726/
https://www.ncbi.nlm.nih.gov/pubmed/29943290
http://dx.doi.org/10.1007/s10928-018-9597-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182726/
https://www.ncbi.nlm.nih.gov/pubmed/29943290
http://dx.doi.org/10.1007/s10928-018-9597-6

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