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Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study
OBJECTIVE: Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182791/ https://www.ncbi.nlm.nih.gov/pubmed/30309393 http://dx.doi.org/10.1186/s13104-018-3819-2 |
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author | Kopczynska, Maja Sharif, Ben Cleaver, Sian Spencer, Naomi Kurani, Amit Lee, Camilla Davis, Jessica Durie, Carys Joseph-Gubral, Jude Sharma, Angelica Allen, Lucy Atkins, Billie Gordon, Alex Jones, Llewelyn Noble, Amy Bradley, Matthew Atkinson, Henry Inns, Joy Penney, Harriet Gilbert, Carys Walford, Rebecca Pike, Louise Edwards, Ross Howcroft, Robyn Preston, Hazel Gee, Jennifer Doyle, Nicholas Maden, Charlotte Smith, Claire Nik Azis, Nik Syakirah Vadivale, Navrhinaa Szakmany, Tamas |
author_facet | Kopczynska, Maja Sharif, Ben Cleaver, Sian Spencer, Naomi Kurani, Amit Lee, Camilla Davis, Jessica Durie, Carys Joseph-Gubral, Jude Sharma, Angelica Allen, Lucy Atkins, Billie Gordon, Alex Jones, Llewelyn Noble, Amy Bradley, Matthew Atkinson, Henry Inns, Joy Penney, Harriet Gilbert, Carys Walford, Rebecca Pike, Louise Edwards, Ross Howcroft, Robyn Preston, Hazel Gee, Jennifer Doyle, Nicholas Maden, Charlotte Smith, Claire Nik Azis, Nik Syakirah Vadivale, Navrhinaa Szakmany, Tamas |
author_sort | Kopczynska, Maja |
collection | PubMed |
description | OBJECTIVE: Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments. RESULTS: 839 patients were recruited over the two 24-h periods in 2016 and 2017. 521 patients fulfilled SEPSIS-3 criteria. 166 patients (32.4%) with sepsis and 56 patients (17.6%) without sepsis died within 90 days. Out of the 166 sepsis deaths 12 (7.2%) could have been directly related to sepsis, 28 (16.9%) possibly related and 96 (57.8%) were not related to sepsis. Overall AFsepsis was 24.1%. Upon analysis of the 40 deaths likely to be attributable to sepsis, we found that 31 patients (77.5%) had the Clinical Frailty Score ≥ 6, 28 (70%) had existing DNA-CPR order and 17 had limitations of care orders (42.5%). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3819-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6182791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61827912018-10-18 Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study Kopczynska, Maja Sharif, Ben Cleaver, Sian Spencer, Naomi Kurani, Amit Lee, Camilla Davis, Jessica Durie, Carys Joseph-Gubral, Jude Sharma, Angelica Allen, Lucy Atkins, Billie Gordon, Alex Jones, Llewelyn Noble, Amy Bradley, Matthew Atkinson, Henry Inns, Joy Penney, Harriet Gilbert, Carys Walford, Rebecca Pike, Louise Edwards, Ross Howcroft, Robyn Preston, Hazel Gee, Jennifer Doyle, Nicholas Maden, Charlotte Smith, Claire Nik Azis, Nik Syakirah Vadivale, Navrhinaa Szakmany, Tamas BMC Res Notes Research Note OBJECTIVE: Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments. RESULTS: 839 patients were recruited over the two 24-h periods in 2016 and 2017. 521 patients fulfilled SEPSIS-3 criteria. 166 patients (32.4%) with sepsis and 56 patients (17.6%) without sepsis died within 90 days. Out of the 166 sepsis deaths 12 (7.2%) could have been directly related to sepsis, 28 (16.9%) possibly related and 96 (57.8%) were not related to sepsis. Overall AFsepsis was 24.1%. Upon analysis of the 40 deaths likely to be attributable to sepsis, we found that 31 patients (77.5%) had the Clinical Frailty Score ≥ 6, 28 (70%) had existing DNA-CPR order and 17 had limitations of care orders (42.5%). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3819-2) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-11 /pmc/articles/PMC6182791/ /pubmed/30309393 http://dx.doi.org/10.1186/s13104-018-3819-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Kopczynska, Maja Sharif, Ben Cleaver, Sian Spencer, Naomi Kurani, Amit Lee, Camilla Davis, Jessica Durie, Carys Joseph-Gubral, Jude Sharma, Angelica Allen, Lucy Atkins, Billie Gordon, Alex Jones, Llewelyn Noble, Amy Bradley, Matthew Atkinson, Henry Inns, Joy Penney, Harriet Gilbert, Carys Walford, Rebecca Pike, Louise Edwards, Ross Howcroft, Robyn Preston, Hazel Gee, Jennifer Doyle, Nicholas Maden, Charlotte Smith, Claire Nik Azis, Nik Syakirah Vadivale, Navrhinaa Szakmany, Tamas Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study |
title | Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study |
title_full | Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study |
title_fullStr | Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study |
title_full_unstemmed | Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study |
title_short | Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study |
title_sort | sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182791/ https://www.ncbi.nlm.nih.gov/pubmed/30309393 http://dx.doi.org/10.1186/s13104-018-3819-2 |
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