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Visceral pain: gut microbiota, a new hope?

BACKGROUND: Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures. Recent findings have linked the microbiota t...

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Detalles Bibliográficos
Autores principales: Pusceddu, Matteo M, Gareau, Melanie G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182804/
https://www.ncbi.nlm.nih.gov/pubmed/30309367
http://dx.doi.org/10.1186/s12929-018-0476-7
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author Pusceddu, Matteo M
Gareau, Melanie G
author_facet Pusceddu, Matteo M
Gareau, Melanie G
author_sort Pusceddu, Matteo M
collection PubMed
description BACKGROUND: Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures. Recent findings have linked the microbiota to gastrointestinal disorders characterized by abdominal pain suggesting the ability of microbes to modulate visceral hypersensitivity and nociception to pain. MAIN BODY: In this review we describe the neuroanatomical basis of visceral pain signaling and the existing evidence of its manipulation exerted by the gut microbiota. We included an updated overview of the potential therapeutic effects of dietary intervention, specifically probiotics and prebiotics, in alleviating hypersensitivity to visceral pain stimuli. CONCLUSIONS: The gut microbiota dramatically impacts normal visceral pain sensation and affects the mechanisms mediating visceral nociception. Furthermore, manipulation of the gut microbiota using prebiotics and probiotics plays a potential role in the regulation of visceral pain disorders.
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spelling pubmed-61828042018-10-18 Visceral pain: gut microbiota, a new hope? Pusceddu, Matteo M Gareau, Melanie G J Biomed Sci Review BACKGROUND: Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures. Recent findings have linked the microbiota to gastrointestinal disorders characterized by abdominal pain suggesting the ability of microbes to modulate visceral hypersensitivity and nociception to pain. MAIN BODY: In this review we describe the neuroanatomical basis of visceral pain signaling and the existing evidence of its manipulation exerted by the gut microbiota. We included an updated overview of the potential therapeutic effects of dietary intervention, specifically probiotics and prebiotics, in alleviating hypersensitivity to visceral pain stimuli. CONCLUSIONS: The gut microbiota dramatically impacts normal visceral pain sensation and affects the mechanisms mediating visceral nociception. Furthermore, manipulation of the gut microbiota using prebiotics and probiotics plays a potential role in the regulation of visceral pain disorders. BioMed Central 2018-10-11 /pmc/articles/PMC6182804/ /pubmed/30309367 http://dx.doi.org/10.1186/s12929-018-0476-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Pusceddu, Matteo M
Gareau, Melanie G
Visceral pain: gut microbiota, a new hope?
title Visceral pain: gut microbiota, a new hope?
title_full Visceral pain: gut microbiota, a new hope?
title_fullStr Visceral pain: gut microbiota, a new hope?
title_full_unstemmed Visceral pain: gut microbiota, a new hope?
title_short Visceral pain: gut microbiota, a new hope?
title_sort visceral pain: gut microbiota, a new hope?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182804/
https://www.ncbi.nlm.nih.gov/pubmed/30309367
http://dx.doi.org/10.1186/s12929-018-0476-7
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