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Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a study

BACKGROUND: PQ912 is an inhibitor of the glutaminyl cyclase enzyme that plays a central role in the formation of synaptotoxic pyroglutamate-A-beta oligomers. We report on the first clinical study with PQ912 in subjects with biomarker-proven Alzheimer’s disease (AD). The aim was to determine the maxi...

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Detalles Bibliográficos
Autores principales:	Scheltens, Philip, Hallikainen, Merja, Grimmer, Timo, Duning, Thomas, Gouw, Alida A, Teunissen, Charlotte E, Wink, Alle Meije, Maruff, Paul, Harrison, John, van Baal, Caroline M, Bruins, Suzanne, Lues, Inge, Prins, Niels D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182869/ https://www.ncbi.nlm.nih.gov/pubmed/30309389 http://dx.doi.org/10.1186/s13195-018-0431-6

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