Sulfonylureas at the Glomerular Battlefield

The kidney is important in the context of diabetes not only because it is involved in normal glucose homeostasis, but also because it is one of the most important end organs to be involved in diabetes complications. Glomeruli are the meeting point of both microvascular, or renal; and macrovascular,...

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Detalles Bibliográficos
Autores principales: Kalra, Sanjay, Khandelwal, Deepak, Bajaj, Sarita, Das, Ashok Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Touch Medical Media 2018
Materias:
Diabetes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182921/
https://www.ncbi.nlm.nih.gov/pubmed/30349588
http://dx.doi.org/10.17925/EE.2018.14.2.15
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author Kalra, Sanjay
Khandelwal, Deepak
Bajaj, Sarita
Das, Ashok Kumar
author_facet Kalra, Sanjay
Khandelwal, Deepak
Bajaj, Sarita
Das, Ashok Kumar
author_sort Kalra, Sanjay
collection PubMed
description The kidney is important in the context of diabetes not only because it is involved in normal glucose homeostasis, but also because it is one of the most important end organs to be involved in diabetes complications. Glomeruli are the meeting point of both microvascular, or renal; and macrovascular, or cardiovascular, health in diabetes. Sulfonylureas are effective glucose-lowering drugs. While a sulfonylurea-based glucose-lowering strategy is nephro-safe and nephro-protective, this aspect of sulfonylurea pharmaco-biology has not been highlighted earlier. In this editorial, we discuss current preclinical and clinical trial evidence regarding the performance of modern sulfonylureas at the glomerular battlefield.
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spelling pubmed-61829212018-10-22 Sulfonylureas at the Glomerular Battlefield Kalra, Sanjay Khandelwal, Deepak Bajaj, Sarita Das, Ashok Kumar Eur Endocrinol Diabetes The kidney is important in the context of diabetes not only because it is involved in normal glucose homeostasis, but also because it is one of the most important end organs to be involved in diabetes complications. Glomeruli are the meeting point of both microvascular, or renal; and macrovascular, or cardiovascular, health in diabetes. Sulfonylureas are effective glucose-lowering drugs. While a sulfonylurea-based glucose-lowering strategy is nephro-safe and nephro-protective, this aspect of sulfonylurea pharmaco-biology has not been highlighted earlier. In this editorial, we discuss current preclinical and clinical trial evidence regarding the performance of modern sulfonylureas at the glomerular battlefield. Touch Medical Media 2018-09 2018-09-10 /pmc/articles/PMC6182921/ /pubmed/30349588 http://dx.doi.org/10.17925/EE.2018.14.2.15 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/3.0/ This article is published under the Creative Commons Attribution Noncommercial License, which permits any non-commercial use, distribution, adaptation and reproduction provided the original author(s) and source are given appropriate credit. © The Authors 2018. Review Process: This article is a short opinion piece and has not been submitted to external peer reviewers, but was reviewed for accuracy by the editorial board before publication. Authorship: All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship of this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval to the version to be published.
spellingShingle Diabetes
Kalra, Sanjay
Khandelwal, Deepak
Bajaj, Sarita
Das, Ashok Kumar
Sulfonylureas at the Glomerular Battlefield
title Sulfonylureas at the Glomerular Battlefield
title_full Sulfonylureas at the Glomerular Battlefield
title_fullStr Sulfonylureas at the Glomerular Battlefield
title_full_unstemmed Sulfonylureas at the Glomerular Battlefield
title_short Sulfonylureas at the Glomerular Battlefield
title_sort sulfonylureas at the glomerular battlefield
topic Diabetes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182921/
https://www.ncbi.nlm.nih.gov/pubmed/30349588
http://dx.doi.org/10.17925/EE.2018.14.2.15
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AT khandelwaldeepak sulfonylureasattheglomerularbattlefield
AT bajajsarita sulfonylureasattheglomerularbattlefield
AT dasashokkumar sulfonylureasattheglomerularbattlefield

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