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SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes

Previous studies have shown that sirtuin 1 (SIRT1) reduces the production of neuronal amyloid beta (Aβ) and inhibits the inflammatory response of glial cells, thereby generating a neuroprotective effect against Aβ neurotoxicity in animal models of Alzheimer's disease. However, the protective ef...

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Detalles Bibliográficos
Autores principales:	Li, Min-Zhe, Zheng, Liang-Jun, Shen, Jian, Li, Xin-Ya, Zhang, Qi, Bai, Xue, Wang, Qing-Song, Ji, Jian-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183050/ https://www.ncbi.nlm.nih.gov/pubmed/30233076 http://dx.doi.org/10.4103/1673-5374.239449

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