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Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques

HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p27(Gag) and HIV-1 Env and found that priming vacci...

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Detalles Bibliográficos
Autores principales:	Hu, Xintao, Lu, Zhongyan, Valentin, Antonio, Rosati, Margherita, Broderick, Kate E., Sardesai, Niranjan Y., Marx, Preston A., Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183272/ https://www.ncbi.nlm.nih.gov/pubmed/29939820 http://dx.doi.org/10.1080/21645515.2018.1489949

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