In tumor cells, thyroid hormone analogues non-immunologically regulate PD-L1 and PD-1 accumulation that is anti-apoptotic

The PD-1/PD-L1 immune checkpoint involving tumor cells and host immune defense lymphocytes is a well-studied therapeutic target in oncology. That PD-1 and PD-L1 may have additional functions within tumor cells that are independent of the checkpoint is indicated by actions of a thyroid hormone analog...

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Detalles Bibliográficos
Autores principales: Lin, Hung-Yun, Chin, Yu-Tang, Shih, Ya-Jung, Chen, Yi-Ru, Leinung, Matthew, Keating, Kelly A., Mousa, Shaker A., Davis, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183344/
https://www.ncbi.nlm.nih.gov/pubmed/30344919
http://dx.doi.org/10.18632/oncotarget.26143

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