Transform-MinER: transforming molecules in enzyme reactions

MOTIVATION: One goal of synthetic biology is to make new enzymes to generate new products, but identifying the starting enzymes for further investigation is often elusive and relies on expert knowledge, intensive literature searching and trial and error. RESULTS: We present Transform Molecules in En...

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Detalles Bibliográficos
Autores principales: Tyzack, Jonathan D, Ribeiro, Antonio J M, Borkakoti, Neera, Thornton, Janet M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184704/
https://www.ncbi.nlm.nih.gov/pubmed/29762650
http://dx.doi.org/10.1093/bioinformatics/bty394
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author Tyzack, Jonathan D
Ribeiro, Antonio J M
Borkakoti, Neera
Thornton, Janet M
author_facet Tyzack, Jonathan D
Ribeiro, Antonio J M
Borkakoti, Neera
Thornton, Janet M
author_sort Tyzack, Jonathan D
collection PubMed
description MOTIVATION: One goal of synthetic biology is to make new enzymes to generate new products, but identifying the starting enzymes for further investigation is often elusive and relies on expert knowledge, intensive literature searching and trial and error. RESULTS: We present Transform Molecules in Enzyme Reactions, an online computational tool that transforms query substrate molecules into products using enzyme reactions. The most similar native enzyme reactions for each transformation are found, highlighting those that may be of most interest for enzyme design and directed evolution approaches. AVAILABILITY AND IMPLEMENTATION: https://www.ebi.ac.uk/thornton-srv/transform-miner
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spelling pubmed-61847042018-10-18 Transform-MinER: transforming molecules in enzyme reactions Tyzack, Jonathan D Ribeiro, Antonio J M Borkakoti, Neera Thornton, Janet M Bioinformatics Applications Notes MOTIVATION: One goal of synthetic biology is to make new enzymes to generate new products, but identifying the starting enzymes for further investigation is often elusive and relies on expert knowledge, intensive literature searching and trial and error. RESULTS: We present Transform Molecules in Enzyme Reactions, an online computational tool that transforms query substrate molecules into products using enzyme reactions. The most similar native enzyme reactions for each transformation are found, highlighting those that may be of most interest for enzyme design and directed evolution approaches. AVAILABILITY AND IMPLEMENTATION: https://www.ebi.ac.uk/thornton-srv/transform-miner Oxford University Press 2018-10-15 2018-05-14 /pmc/articles/PMC6184704/ /pubmed/29762650 http://dx.doi.org/10.1093/bioinformatics/bty394 Text en © The Author(s) 2018. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Applications Notes
Tyzack, Jonathan D
Ribeiro, Antonio J M
Borkakoti, Neera
Thornton, Janet M
Transform-MinER: transforming molecules in enzyme reactions
title Transform-MinER: transforming molecules in enzyme reactions
title_full Transform-MinER: transforming molecules in enzyme reactions
title_fullStr Transform-MinER: transforming molecules in enzyme reactions
title_full_unstemmed Transform-MinER: transforming molecules in enzyme reactions
title_short Transform-MinER: transforming molecules in enzyme reactions
title_sort transform-miner: transforming molecules in enzyme reactions
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184704/
https://www.ncbi.nlm.nih.gov/pubmed/29762650
http://dx.doi.org/10.1093/bioinformatics/bty394
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