UBE2G1 governs the destruction of cereblon neomorphic substrates

The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4(CRBN)) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjunction with E2 ubiquitin-conjugating enzymes, whi...

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Detalles Bibliográficos
Autores principales: Lu, Gang, Weng, Stephanie, Matyskiela, Mary, Zheng, Xinde, Fang, Wei, Wood, Scott, Surka, Christine, Mizukoshi, Reina, Lu, Chin-Chun, Mendy, Derek, Jang, In Sock, Wang, Kai, Marella, Mathieu, Couto, Suzana, Cathers, Brian, Carmichael, James, Chamberlain, Philip, Rolfe, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185104/
https://www.ncbi.nlm.nih.gov/pubmed/30234487
http://dx.doi.org/10.7554/eLife.40958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185104/
https://www.ncbi.nlm.nih.gov/pubmed/30234487
http://dx.doi.org/10.7554/eLife.40958

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