Cargando…

UBE2G1 governs the destruction of cereblon neomorphic substrates

The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4(CRBN)) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjunction with E2 ubiquitin-conjugating enzymes, whi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Gang, Weng, Stephanie, Matyskiela, Mary, Zheng, Xinde, Fang, Wei, Wood, Scott, Surka, Christine, Mizukoshi, Reina, Lu, Chin-Chun, Mendy, Derek, Jang, In Sock, Wang, Kai, Marella, Mathieu, Couto, Suzana, Cathers, Brian, Carmichael, James, Chamberlain, Philip, Rolfe, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185104/ https://www.ncbi.nlm.nih.gov/pubmed/30234487 http://dx.doi.org/10.7554/eLife.40958

Ejemplares similares

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether
por: Torres, Sandra Elizabeth, et al.
Publicado: (2019)

Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
por: Fiehn, Oliver, et al.
Publicado: (2016)

Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
por: Showalter, Megan Reed, et al.
Publicado: (2017)

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation
por: Greene, Eric R, et al.
Publicado: (2019)

LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex
por: Canny, Marella D, et al.
Publicado: (2022)

The destructive effect of botulinum neurotoxins on the SNARE protein: SNAP-25 and synaptic membrane fusion
por: Lu, Bin
Publicado: (2015)

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
por: Lopez-Girona, A, et al.
Publicado: (2012)

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
por: Lopez-Girona, A, et al.
Publicado: (2012)

Data for positive selection test and co-evolutionary analysis on mammalian cereblon
por: Onodera, Wataru, et al.
Publicado: (2019)

Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo
por: Akingbesote, Ngozi D, et al.
Publicado: (2023)

Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity
por: Gandhi, Anita K, et al.
Publicado: (2014)

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1
por: Trinh, Michael Nguyen, et al.
Publicado: (2018)

Transposase-assisted tagmentation of RNA/DNA hybrid duplexes
por: Lu, Bo, et al.
Publicado: (2020)

Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform
por: Xia, Yifeng, et al.
Publicado: (2021)

Correction: The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity
por: Sirey, Tamara M, et al.
Publicado: (2019)

The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity
por: Sirey, Tamara M, et al.
Publicado: (2019)

Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2
por: Liauw, Brandon Wey-Hung, et al.
Publicado: (2022)

Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode
por: Hu, Lu, et al.
Publicado: (2022)

Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death
por: Lu, Kuan-Yi, et al.
Publicado: (2020)

Fusion surface structure, function, and dynamics of gamete fusogen HAP2
por: Feng, Juan, et al.
Publicado: (2018)

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
por: Saha, Piyali, et al.
Publicado: (2020)

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation
por: Lv, Lu, et al.
Publicado: (2020)

Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10
por: Li, Jingxiang, et al.
Publicado: (2021)

A Dual Color Immunohistochemistry Assay for Measurement of Cereblon in Multiple Myeloma Patient Samples
por: Ren, Yan, et al.
Publicado: (2016)

Chronic Ca(2+) imaging of cortical neurons with long-term expression of GCaMP-X
por: Geng, Jinli, et al.
Publicado: (2022)

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology
por: Zhang, Shengnan, et al.
Publicado: (2022)

Association of egg consumption, metabolic markers, and risk of cardiovascular diseases: A nested case-control study
por: Pan, Lang, et al.
Publicado: (2022)

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry
por: Wei, Tiantian, et al.
Publicado: (2022)

Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau
por: Ma, Xiaojuan, et al.
Publicado: (2020)

A subcellular map of the human kinome
por: Zhang, Haitao, et al.
Publicado: (2021)

Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis
por: Molnar, Cristina, et al.
Publicado: (2022)

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
por: Zhang, Li, et al.
Publicado: (2015)

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
por: Fan, Mengyang, et al.
Publicado: (2022)

Chemical Ligand Space of Cereblon
por: Boichenko, Iuliia, et al.
Publicado: (2018)

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
por: Zhang, Dao-Lai, et al.
Publicado: (2018)

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
por: Suh, Jae Myoung, et al.
Publicado: (2014)

Targeted protein degradation bypassing cereblon and von Hippel-Lindau
por: Lu, Wenchao
Publicado: (2023)

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
por: Overman, Jeroen, et al.
Publicado: (2017)

Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation
por: Mourão, André, et al.
Publicado: (2016)

The gating cycle of a K(+) channel at atomic resolution
por: Cuello, Luis G, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_lo5q7olf705h4clqa7m19nd60m