Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, while the colon of Rnf5(−/−) mice exhibits activated dendritic...

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Detalles Bibliográficos
Autores principales: Fujita, Yu, Khateb, Ali, Li, Yan, Tinoco, Roberto, Zhang, Tongwu, Bar-Yoseph, Haggai, Tam, Miguel A., Chowers, Yehuda, Sabo, Edmond, Gerassy-Vainberg, Shiran, Starosvetsky, Elina, James, Brian, Brown, Kevin, Shen-Orr, Shai S., Bradley, Linda M., Tessier, Philippe A., Ronai, Ze’ev A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185744/
https://www.ncbi.nlm.nih.gov/pubmed/30232010
http://dx.doi.org/10.1016/j.celrep.2018.08.057

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