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Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene

The c-MYC oncogene mediates multiple tumor cell survival pathways and is dysregulated or overexpressed in the majority of human cancers. The NHE III(1) region of the c-MYC promoter forms a DNA quadruplex. Stabilization of this structure with small molecules has been shown to reduce expression of c-M...

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Detalles Bibliográficos
Autores principales:	Stump, Sascha, Mou, Tung-Chung, Sprang, Stephen R., Natale, Nicholas R., Beall, Howard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185859/ https://www.ncbi.nlm.nih.gov/pubmed/30312328 http://dx.doi.org/10.1371/journal.pone.0205584

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