Cargando…
HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth
Eliciting antibodies that neutralize a broad range of circulating HIV strains (broadly neutralizing antibodies [bnAbs]) represents a key priority for vaccine development. HIV superinfection (re-infection with a second strain following an established infection) has been associated with neutralization...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185870/ https://www.ncbi.nlm.nih.gov/pubmed/30269971 http://dx.doi.org/10.1016/j.chom.2018.09.001 |
_version_ | 1783362757477793792 |
---|---|
author | Sheward, Daniel J. Marais, Jinny Bekker, Valerie Murrell, Ben Eren, Kemal Bhiman, Jinal N. Nonyane, Molati Garrett, Nigel Woodman, Zenda L. Abdool Karim, Quarraisha Abdool Karim, Salim S. Morris, Lynn Moore, Penny L. Williamson, Carolyn |
author_facet | Sheward, Daniel J. Marais, Jinny Bekker, Valerie Murrell, Ben Eren, Kemal Bhiman, Jinal N. Nonyane, Molati Garrett, Nigel Woodman, Zenda L. Abdool Karim, Quarraisha Abdool Karim, Salim S. Morris, Lynn Moore, Penny L. Williamson, Carolyn |
author_sort | Sheward, Daniel J. |
collection | PubMed |
description | Eliciting antibodies that neutralize a broad range of circulating HIV strains (broadly neutralizing antibodies [bnAbs]) represents a key priority for vaccine development. HIV superinfection (re-infection with a second strain following an established infection) has been associated with neutralization breadth, and can provide insights into how the immune system responds to sequential exposure to distinct HIV envelope glycoproteins (Env). Characterizing the neutralizing antibody (nAb) responses in four superinfected women revealed that superinfection does not boost memory nAb responses primed by the first infection or promote nAb responses to epitopes conserved in both infecting viruses. While one superinfected individual developed potent bnAbs, superinfection was likely not the driver as the nAb response did not target an epitope conserved in both viruses. Rather, sequential exposure led to nAbs specific to each Env but did not promote bnAb development. Thus, sequential immunization with heterologous Envs may not be sufficient to focus the immune response onto conserved epitopes. |
format | Online Article Text |
id | pubmed-6185870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61858702018-10-15 HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth Sheward, Daniel J. Marais, Jinny Bekker, Valerie Murrell, Ben Eren, Kemal Bhiman, Jinal N. Nonyane, Molati Garrett, Nigel Woodman, Zenda L. Abdool Karim, Quarraisha Abdool Karim, Salim S. Morris, Lynn Moore, Penny L. Williamson, Carolyn Cell Host Microbe Article Eliciting antibodies that neutralize a broad range of circulating HIV strains (broadly neutralizing antibodies [bnAbs]) represents a key priority for vaccine development. HIV superinfection (re-infection with a second strain following an established infection) has been associated with neutralization breadth, and can provide insights into how the immune system responds to sequential exposure to distinct HIV envelope glycoproteins (Env). Characterizing the neutralizing antibody (nAb) responses in four superinfected women revealed that superinfection does not boost memory nAb responses primed by the first infection or promote nAb responses to epitopes conserved in both infecting viruses. While one superinfected individual developed potent bnAbs, superinfection was likely not the driver as the nAb response did not target an epitope conserved in both viruses. Rather, sequential exposure led to nAbs specific to each Env but did not promote bnAb development. Thus, sequential immunization with heterologous Envs may not be sufficient to focus the immune response onto conserved epitopes. Cell Press 2018-10-10 /pmc/articles/PMC6185870/ /pubmed/30269971 http://dx.doi.org/10.1016/j.chom.2018.09.001 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sheward, Daniel J. Marais, Jinny Bekker, Valerie Murrell, Ben Eren, Kemal Bhiman, Jinal N. Nonyane, Molati Garrett, Nigel Woodman, Zenda L. Abdool Karim, Quarraisha Abdool Karim, Salim S. Morris, Lynn Moore, Penny L. Williamson, Carolyn HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth |
title | HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth |
title_full | HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth |
title_fullStr | HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth |
title_full_unstemmed | HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth |
title_short | HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth |
title_sort | hiv superinfection drives de novo antibody responses and not neutralization breadth |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185870/ https://www.ncbi.nlm.nih.gov/pubmed/30269971 http://dx.doi.org/10.1016/j.chom.2018.09.001 |
work_keys_str_mv | AT shewarddanielj hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT maraisjinny hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT bekkervalerie hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT murrellben hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT erenkemal hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT bhimanjinaln hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT nonyanemolati hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT garrettnigel hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT woodmanzendal hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT abdoolkarimquarraisha hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT abdoolkarimsalims hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT morrislynn hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT moorepennyl hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth AT williamsoncarolyn hivsuperinfectiondrivesdenovoantibodyresponsesandnotneutralizationbreadth |