Cargando…
Regional adiposity and markers of inflammation in pre-school age children
In adults, upper body fat partially increases metabolic disease risk through increasing systemic inflammation. Our objective was to determine if this relationship exists in preschool-aged children. A subset of children (n = 71, 35 males), 3.7 ± 1.0 y, were studied from n = 515 children recruited fro...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185945/ https://www.ncbi.nlm.nih.gov/pubmed/30315178 http://dx.doi.org/10.1038/s41598-018-33054-1 |
_version_ | 1783362774872621056 |
---|---|
author | Delaney, Kerri Z. Vanstone, Catherine A. Weiler, Hope A. Santosa, Sylvia |
author_facet | Delaney, Kerri Z. Vanstone, Catherine A. Weiler, Hope A. Santosa, Sylvia |
author_sort | Delaney, Kerri Z. |
collection | PubMed |
description | In adults, upper body fat partially increases metabolic disease risk through increasing systemic inflammation. Our objective was to determine if this relationship exists in preschool-aged children. A subset of children (n = 71, 35 males), 3.7 ± 1.0 y, were studied from n = 515 children recruited from randomly selected daycares in Montréal, QC. According to WHO charts for 2–5 y, 49 children were healthy weight (HW) and 21 were overweight (OW). Adiposity was determined through dual-energy x-ray absorptiometry. Blood concentrations of C-reactive protein (CRP) and tumour necrosis factor alpha (TNFα) were determined via enzyme-linked immunosorbent and multiplex assays, respectively. OW children had higher (p = 0.03) android:gynoid ratio 0.50 ± 0.09 compared to HW children 0.56 ± 0.12, indicating excess fat was predominantly stored in the abdominal depot. CRP was higher (p = 0.01) in OW children 1.45 ± 2.02 mg/L compared to HW 0.74 ± 1.38 mg/L. Percent fat was correlated with CRP (r = 0.32; p < 0.01) and TNFα (r = 0.25; p = 0.04) concentrations. CRP also correlated with android adiposity (r = 0.24; p = 0.04) and TNFα correlated with gynoid adiposity (r = 0.24; p = 0.04). We observed that greater adiposity is associated with higher systemic inflammation in pre-school aged children. Future longitudinal studies are needed to understand the long term consequences of excess total and regional body fat in young children. |
format | Online Article Text |
id | pubmed-6185945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61859452018-10-15 Regional adiposity and markers of inflammation in pre-school age children Delaney, Kerri Z. Vanstone, Catherine A. Weiler, Hope A. Santosa, Sylvia Sci Rep Article In adults, upper body fat partially increases metabolic disease risk through increasing systemic inflammation. Our objective was to determine if this relationship exists in preschool-aged children. A subset of children (n = 71, 35 males), 3.7 ± 1.0 y, were studied from n = 515 children recruited from randomly selected daycares in Montréal, QC. According to WHO charts for 2–5 y, 49 children were healthy weight (HW) and 21 were overweight (OW). Adiposity was determined through dual-energy x-ray absorptiometry. Blood concentrations of C-reactive protein (CRP) and tumour necrosis factor alpha (TNFα) were determined via enzyme-linked immunosorbent and multiplex assays, respectively. OW children had higher (p = 0.03) android:gynoid ratio 0.50 ± 0.09 compared to HW children 0.56 ± 0.12, indicating excess fat was predominantly stored in the abdominal depot. CRP was higher (p = 0.01) in OW children 1.45 ± 2.02 mg/L compared to HW 0.74 ± 1.38 mg/L. Percent fat was correlated with CRP (r = 0.32; p < 0.01) and TNFα (r = 0.25; p = 0.04) concentrations. CRP also correlated with android adiposity (r = 0.24; p = 0.04) and TNFα correlated with gynoid adiposity (r = 0.24; p = 0.04). We observed that greater adiposity is associated with higher systemic inflammation in pre-school aged children. Future longitudinal studies are needed to understand the long term consequences of excess total and regional body fat in young children. Nature Publishing Group UK 2018-10-12 /pmc/articles/PMC6185945/ /pubmed/30315178 http://dx.doi.org/10.1038/s41598-018-33054-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Delaney, Kerri Z. Vanstone, Catherine A. Weiler, Hope A. Santosa, Sylvia Regional adiposity and markers of inflammation in pre-school age children |
title | Regional adiposity and markers of inflammation in pre-school age children |
title_full | Regional adiposity and markers of inflammation in pre-school age children |
title_fullStr | Regional adiposity and markers of inflammation in pre-school age children |
title_full_unstemmed | Regional adiposity and markers of inflammation in pre-school age children |
title_short | Regional adiposity and markers of inflammation in pre-school age children |
title_sort | regional adiposity and markers of inflammation in pre-school age children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185945/ https://www.ncbi.nlm.nih.gov/pubmed/30315178 http://dx.doi.org/10.1038/s41598-018-33054-1 |
work_keys_str_mv | AT delaneykerriz regionaladiposityandmarkersofinflammationinpreschoolagechildren AT vanstonecatherinea regionaladiposityandmarkersofinflammationinpreschoolagechildren AT weilerhopea regionaladiposityandmarkersofinflammationinpreschoolagechildren AT santosasylvia regionaladiposityandmarkersofinflammationinpreschoolagechildren |