Cargando…

Regional adiposity and markers of inflammation in pre-school age children

In adults, upper body fat partially increases metabolic disease risk through increasing systemic inflammation. Our objective was to determine if this relationship exists in preschool-aged children. A subset of children (n = 71, 35 males), 3.7 ± 1.0 y, were studied from n = 515 children recruited fro...

Descripción completa

Detalles Bibliográficos
Autores principales: Delaney, Kerri Z., Vanstone, Catherine A., Weiler, Hope A., Santosa, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185945/
https://www.ncbi.nlm.nih.gov/pubmed/30315178
http://dx.doi.org/10.1038/s41598-018-33054-1
_version_ 1783362774872621056
author Delaney, Kerri Z.
Vanstone, Catherine A.
Weiler, Hope A.
Santosa, Sylvia
author_facet Delaney, Kerri Z.
Vanstone, Catherine A.
Weiler, Hope A.
Santosa, Sylvia
author_sort Delaney, Kerri Z.
collection PubMed
description In adults, upper body fat partially increases metabolic disease risk through increasing systemic inflammation. Our objective was to determine if this relationship exists in preschool-aged children. A subset of children (n = 71, 35 males), 3.7 ± 1.0 y, were studied from n = 515 children recruited from randomly selected daycares in Montréal, QC. According to WHO charts for 2–5 y, 49 children were healthy weight (HW) and 21 were overweight (OW). Adiposity was determined through dual-energy x-ray absorptiometry. Blood concentrations of C-reactive protein (CRP) and tumour necrosis factor alpha (TNFα) were determined via enzyme-linked immunosorbent and multiplex assays, respectively. OW children had higher (p = 0.03) android:gynoid ratio 0.50 ± 0.09 compared to HW children 0.56 ± 0.12, indicating excess fat was predominantly stored in the abdominal depot. CRP was higher (p = 0.01) in OW children 1.45 ± 2.02 mg/L compared to HW 0.74 ± 1.38 mg/L. Percent fat was correlated with CRP (r = 0.32; p < 0.01) and TNFα (r = 0.25; p = 0.04) concentrations. CRP also correlated with android adiposity (r = 0.24; p = 0.04) and TNFα correlated with gynoid adiposity (r = 0.24; p = 0.04). We observed that greater adiposity is associated with higher systemic inflammation in pre-school aged children. Future longitudinal studies are needed to understand the long term consequences of excess total and regional body fat in young children.
format Online
Article
Text
id pubmed-6185945
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61859452018-10-15 Regional adiposity and markers of inflammation in pre-school age children Delaney, Kerri Z. Vanstone, Catherine A. Weiler, Hope A. Santosa, Sylvia Sci Rep Article In adults, upper body fat partially increases metabolic disease risk through increasing systemic inflammation. Our objective was to determine if this relationship exists in preschool-aged children. A subset of children (n = 71, 35 males), 3.7 ± 1.0 y, were studied from n = 515 children recruited from randomly selected daycares in Montréal, QC. According to WHO charts for 2–5 y, 49 children were healthy weight (HW) and 21 were overweight (OW). Adiposity was determined through dual-energy x-ray absorptiometry. Blood concentrations of C-reactive protein (CRP) and tumour necrosis factor alpha (TNFα) were determined via enzyme-linked immunosorbent and multiplex assays, respectively. OW children had higher (p = 0.03) android:gynoid ratio 0.50 ± 0.09 compared to HW children 0.56 ± 0.12, indicating excess fat was predominantly stored in the abdominal depot. CRP was higher (p = 0.01) in OW children 1.45 ± 2.02 mg/L compared to HW 0.74 ± 1.38 mg/L. Percent fat was correlated with CRP (r = 0.32; p < 0.01) and TNFα (r = 0.25; p = 0.04) concentrations. CRP also correlated with android adiposity (r = 0.24; p = 0.04) and TNFα correlated with gynoid adiposity (r = 0.24; p = 0.04). We observed that greater adiposity is associated with higher systemic inflammation in pre-school aged children. Future longitudinal studies are needed to understand the long term consequences of excess total and regional body fat in young children. Nature Publishing Group UK 2018-10-12 /pmc/articles/PMC6185945/ /pubmed/30315178 http://dx.doi.org/10.1038/s41598-018-33054-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Delaney, Kerri Z.
Vanstone, Catherine A.
Weiler, Hope A.
Santosa, Sylvia
Regional adiposity and markers of inflammation in pre-school age children
title Regional adiposity and markers of inflammation in pre-school age children
title_full Regional adiposity and markers of inflammation in pre-school age children
title_fullStr Regional adiposity and markers of inflammation in pre-school age children
title_full_unstemmed Regional adiposity and markers of inflammation in pre-school age children
title_short Regional adiposity and markers of inflammation in pre-school age children
title_sort regional adiposity and markers of inflammation in pre-school age children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185945/
https://www.ncbi.nlm.nih.gov/pubmed/30315178
http://dx.doi.org/10.1038/s41598-018-33054-1
work_keys_str_mv AT delaneykerriz regionaladiposityandmarkersofinflammationinpreschoolagechildren
AT vanstonecatherinea regionaladiposityandmarkersofinflammationinpreschoolagechildren
AT weilerhopea regionaladiposityandmarkersofinflammationinpreschoolagechildren
AT santosasylvia regionaladiposityandmarkersofinflammationinpreschoolagechildren