Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex

G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between different G4 structures are rare. Here, we describe D...

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Detalles Bibliográficos
Autores principales: Calabrese, David R., Chen, Xiang, Leon, Elena C., Gaikwad, Snehal M., Phyo, Zaw, Hewitt, William M., Alden, Stephanie, Hilimire, Thomas A., He, Fahu, Michalowski, Aleksandra M., Simmons, John K., Saunders, Lindsey B., Zhang, Shuling, Connors, Daniel, Walters, Kylie J., Mock, Beverly A., Schneekloth, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185959/
https://www.ncbi.nlm.nih.gov/pubmed/30315240
http://dx.doi.org/10.1038/s41467-018-06315-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185959/
https://www.ncbi.nlm.nih.gov/pubmed/30315240
http://dx.doi.org/10.1038/s41467-018-06315-w

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