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Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between different G4 structures are rare. Here, we describe D...
Autores principales: | Calabrese, David R., Chen, Xiang, Leon, Elena C., Gaikwad, Snehal M., Phyo, Zaw, Hewitt, William M., Alden, Stephanie, Hilimire, Thomas A., He, Fahu, Michalowski, Aleksandra M., Simmons, John K., Saunders, Lindsey B., Zhang, Shuling, Connors, Daniel, Walters, Kylie J., Mock, Beverly A., Schneekloth, John S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185959/ https://www.ncbi.nlm.nih.gov/pubmed/30315240 http://dx.doi.org/10.1038/s41467-018-06315-w |
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