A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

The mammalian heart has a limited regenerative capacity and typically progresses to heart failure following injury. Here, we defined a hedgehog (HH)-Gli1-Mycn network for cardiomyocyte proliferation and heart regeneration from amphibians to mammals. Using a genome-wide screen, we verified that HH si...

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Detalles Bibliográficos
Autores principales: Singh, Bhairab N., Koyano-Nakagawa, Naoko, Gong, Wuming, Moskowitz, Ivan P., Weaver, Cyprian V., Braunlin, Elizabeth, Das, Satyabrata, van Berlo, Jop H., Garry, Mary G., Garry, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185975/
https://www.ncbi.nlm.nih.gov/pubmed/30315164
http://dx.doi.org/10.1038/s41467-018-06617-z

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