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Local generation of hydrogen for enhanced photothermal therapy

By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise. Leveraging virtue of versatile abilities of Pd hydride nanomaterials in high/stable hydrogen storage,...

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Autores principales: Zhao, Penghe, Jin, Zhaokui, Chen, Qian, Yang, Tian, Chen, Danyang, Meng, Jin, Lu, Xifeng, Gu, Zhen, He, Qianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185976/
https://www.ncbi.nlm.nih.gov/pubmed/30315173
http://dx.doi.org/10.1038/s41467-018-06630-2
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author Zhao, Penghe
Jin, Zhaokui
Chen, Qian
Yang, Tian
Chen, Danyang
Meng, Jin
Lu, Xifeng
Gu, Zhen
He, Qianjun
author_facet Zhao, Penghe
Jin, Zhaokui
Chen, Qian
Yang, Tian
Chen, Danyang
Meng, Jin
Lu, Xifeng
Gu, Zhen
He, Qianjun
author_sort Zhao, Penghe
collection PubMed
description By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise. Leveraging virtue of versatile abilities of Pd hydride nanomaterials in high/stable hydrogen storage, self-catalytic hydrogenation, near-infrared (NIR) light absorption and photothermal conversion, here we utilize the cubic PdH(0.2) nanocrystals for tumour-targeted and photoacoustic imaging (PAI)-guided hydrogenothermal therapy of cancer. The synthesized PdH(0.2) nanocrystals have exhibited high intratumoural accumulation capability, clear NIR-controlled hydrogen release behaviours, NIR-enhanced self-catalysis bio-reductivity, high NIR-photothermal effect and PAI performance. With these unique properties of PdH(0.2) nanocrystals, synergetic hydrogenothermal therapy with limited systematic toxicity has been achieved by tumour-targeted delivery and PAI-guided NIR-controlled release of bio-reductive hydrogen as well as generation of heat. This hydrogenothermal approach has presented a cancer-selective strategy for synergistic cancer treatment.
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spelling pubmed-61859762018-10-15 Local generation of hydrogen for enhanced photothermal therapy Zhao, Penghe Jin, Zhaokui Chen, Qian Yang, Tian Chen, Danyang Meng, Jin Lu, Xifeng Gu, Zhen He, Qianjun Nat Commun Article By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise. Leveraging virtue of versatile abilities of Pd hydride nanomaterials in high/stable hydrogen storage, self-catalytic hydrogenation, near-infrared (NIR) light absorption and photothermal conversion, here we utilize the cubic PdH(0.2) nanocrystals for tumour-targeted and photoacoustic imaging (PAI)-guided hydrogenothermal therapy of cancer. The synthesized PdH(0.2) nanocrystals have exhibited high intratumoural accumulation capability, clear NIR-controlled hydrogen release behaviours, NIR-enhanced self-catalysis bio-reductivity, high NIR-photothermal effect and PAI performance. With these unique properties of PdH(0.2) nanocrystals, synergetic hydrogenothermal therapy with limited systematic toxicity has been achieved by tumour-targeted delivery and PAI-guided NIR-controlled release of bio-reductive hydrogen as well as generation of heat. This hydrogenothermal approach has presented a cancer-selective strategy for synergistic cancer treatment. Nature Publishing Group UK 2018-10-12 /pmc/articles/PMC6185976/ /pubmed/30315173 http://dx.doi.org/10.1038/s41467-018-06630-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhao, Penghe
Jin, Zhaokui
Chen, Qian
Yang, Tian
Chen, Danyang
Meng, Jin
Lu, Xifeng
Gu, Zhen
He, Qianjun
Local generation of hydrogen for enhanced photothermal therapy
title Local generation of hydrogen for enhanced photothermal therapy
title_full Local generation of hydrogen for enhanced photothermal therapy
title_fullStr Local generation of hydrogen for enhanced photothermal therapy
title_full_unstemmed Local generation of hydrogen for enhanced photothermal therapy
title_short Local generation of hydrogen for enhanced photothermal therapy
title_sort local generation of hydrogen for enhanced photothermal therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185976/
https://www.ncbi.nlm.nih.gov/pubmed/30315173
http://dx.doi.org/10.1038/s41467-018-06630-2
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