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Estimate of prevalent diabetes from cardiometabolic index in general Chinese population: a community-based study

BACKGROUND: Cardiometabolic index (CMI) defines adiposity based on triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and waist-to-height ratio (WHtR). This newly proposed metric has been used to detect multiple cardiovascular risk factors, but data relative to diabetes in the...

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Autores principales: Shi, Wen-Rui, Wang, Hao-Yu, Chen, Shuang, Guo, Xiao-Fan, Li, Zhao, Sun, Ying-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186046/
https://www.ncbi.nlm.nih.gov/pubmed/30314516
http://dx.doi.org/10.1186/s12944-018-0886-2
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author Shi, Wen-Rui
Wang, Hao-Yu
Chen, Shuang
Guo, Xiao-Fan
Li, Zhao
Sun, Ying-Xian
author_facet Shi, Wen-Rui
Wang, Hao-Yu
Chen, Shuang
Guo, Xiao-Fan
Li, Zhao
Sun, Ying-Xian
author_sort Shi, Wen-Rui
collection PubMed
description BACKGROUND: Cardiometabolic index (CMI) defines adiposity based on triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and waist-to-height ratio (WHtR). This newly proposed metric has been used to detect multiple cardiovascular risk factors, but data relative to diabetes in the general population are lacking. This study aims to validate CMI’s utility of discriminating diabetes and compares it with other indexes among general Chinese population. METHODS: Analyses were based on a cross-sectional study of 11,478 participants that underwent assessment of metabolic and anthropometric parameters in rural areas of northeastern China in 2013. CMI was calculated by TG/HDL-C × WHtR. Multivariate logistic regressions were performed to clarify CMI’s association with diabetes, ROC analyses were engaged to investigate CMI’s discriminating ability for diabetes. RESULTS: The prevalence of diabetes was 9.93% in males while 10.76% in females, and increased with CMI’s increment. After full adjustment, each SD increment of CMI had odds ratios (ORs) for diabetes of 1.471 (1.367–1.584) and 1.422 (1.315–1.539) in females and males, respectively. Compared with bottom categories of CMI, the top quartiles had ORs of 3.736 (2.783–5.015) in females and 3.697 (2.757–4.958) in males. The ROC results showed an excellent discriminating power of CMI (AUC: 0.702 for females, 0.664 for males). CONCLUSIONS: An increasing CMI was correlated with higher odds of diabetes, supporting CMI as a useful and economic measure to screen and quantify diabetes in general Chinese population. Monitoring and promoting achievement of dyslipidemia and abdominal obesity based on CMI may improve subclinical and cardiovascular outcomes.
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spelling pubmed-61860462018-10-19 Estimate of prevalent diabetes from cardiometabolic index in general Chinese population: a community-based study Shi, Wen-Rui Wang, Hao-Yu Chen, Shuang Guo, Xiao-Fan Li, Zhao Sun, Ying-Xian Lipids Health Dis Research BACKGROUND: Cardiometabolic index (CMI) defines adiposity based on triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and waist-to-height ratio (WHtR). This newly proposed metric has been used to detect multiple cardiovascular risk factors, but data relative to diabetes in the general population are lacking. This study aims to validate CMI’s utility of discriminating diabetes and compares it with other indexes among general Chinese population. METHODS: Analyses were based on a cross-sectional study of 11,478 participants that underwent assessment of metabolic and anthropometric parameters in rural areas of northeastern China in 2013. CMI was calculated by TG/HDL-C × WHtR. Multivariate logistic regressions were performed to clarify CMI’s association with diabetes, ROC analyses were engaged to investigate CMI’s discriminating ability for diabetes. RESULTS: The prevalence of diabetes was 9.93% in males while 10.76% in females, and increased with CMI’s increment. After full adjustment, each SD increment of CMI had odds ratios (ORs) for diabetes of 1.471 (1.367–1.584) and 1.422 (1.315–1.539) in females and males, respectively. Compared with bottom categories of CMI, the top quartiles had ORs of 3.736 (2.783–5.015) in females and 3.697 (2.757–4.958) in males. The ROC results showed an excellent discriminating power of CMI (AUC: 0.702 for females, 0.664 for males). CONCLUSIONS: An increasing CMI was correlated with higher odds of diabetes, supporting CMI as a useful and economic measure to screen and quantify diabetes in general Chinese population. Monitoring and promoting achievement of dyslipidemia and abdominal obesity based on CMI may improve subclinical and cardiovascular outcomes. BioMed Central 2018-10-12 /pmc/articles/PMC6186046/ /pubmed/30314516 http://dx.doi.org/10.1186/s12944-018-0886-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Shi, Wen-Rui
Wang, Hao-Yu
Chen, Shuang
Guo, Xiao-Fan
Li, Zhao
Sun, Ying-Xian
Estimate of prevalent diabetes from cardiometabolic index in general Chinese population: a community-based study
title Estimate of prevalent diabetes from cardiometabolic index in general Chinese population: a community-based study
title_full Estimate of prevalent diabetes from cardiometabolic index in general Chinese population: a community-based study
title_fullStr Estimate of prevalent diabetes from cardiometabolic index in general Chinese population: a community-based study
title_full_unstemmed Estimate of prevalent diabetes from cardiometabolic index in general Chinese population: a community-based study
title_short Estimate of prevalent diabetes from cardiometabolic index in general Chinese population: a community-based study
title_sort estimate of prevalent diabetes from cardiometabolic index in general chinese population: a community-based study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186046/
https://www.ncbi.nlm.nih.gov/pubmed/30314516
http://dx.doi.org/10.1186/s12944-018-0886-2
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