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Scorer and modality agreement for the detection of intervertebral disc calcification in Dachshunds
BACKGROUND: The Dachshund is a chondrodystrophic breed of dog predisposed to premature degeneration and calcification, and subsequent herniation, of intervertebral discs (IVDs). This condition is heritable in Dachshunds and breeding candidates are screened for radiographically detectable interverteb...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186048/ https://www.ncbi.nlm.nih.gov/pubmed/30316295 http://dx.doi.org/10.1186/s13028-018-0416-2 |
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author | Rosenblatt, Alana Jayne Lappalainen, Anu Katriina James, Nina Alice Webster, Natalie Siu Ling Caraguel, Charles Grégoire Bénédict |
author_facet | Rosenblatt, Alana Jayne Lappalainen, Anu Katriina James, Nina Alice Webster, Natalie Siu Ling Caraguel, Charles Grégoire Bénédict |
author_sort | Rosenblatt, Alana Jayne |
collection | PubMed |
description | BACKGROUND: The Dachshund is a chondrodystrophic breed of dog predisposed to premature degeneration and calcification, and subsequent herniation, of intervertebral discs (IVDs). This condition is heritable in Dachshunds and breeding candidates are screened for radiographically detectable intervertebral disc calcification (RDIDC), a feature of advanced disc degeneration and a prognostic factor for clinical disease. RDIDC scoring has been previously shown to be consistent within scorers; however, strong scorer effect (subjectivity) was also reported. The aim of this study was to estimate the within- and between-scorer agreement (repeatability and reproducibility, respectively) of computed tomography (CT) scanning and magnetic resonance imaging (MRI) for scoring IVD calcification, and to compare these modalities with radiographic scoring. RESULTS: Twenty-one Dachshund dogs were screened for IVD calcification using the three imaging modalities. Three scorers scored each case twice, independently. Repeatability was highest for radiography (95.4%), and significantly higher than for CT (90.4%) but not MRI (93.8%). Reproducibility was also highest for radiography (92.9%), but not significantly higher than for CT or MRI (89.4% and 86.4%, respectively). Overall, CT scored IVDs differently than radiography and MRI (64.8% and 62.7% agreement, respectively), while radiography and MRI scored more similarly (85.7% agreement). CONCLUSIONS: Despite high precision for radiography, previous evidence of scorer subjectivity was confirmed, which was not generally observed with CT and MRI. The increased consistency of radiography may be related to prior scorer experience with the modality and RDIDC scoring. This study does not support replacing radiography with CT or MRI to screen for heritable IVD calcification in breeding Dachshunds; however, evaluation of dog-level precision and the accuracy of each modality is recommended. |
format | Online Article Text |
id | pubmed-6186048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61860482018-10-19 Scorer and modality agreement for the detection of intervertebral disc calcification in Dachshunds Rosenblatt, Alana Jayne Lappalainen, Anu Katriina James, Nina Alice Webster, Natalie Siu Ling Caraguel, Charles Grégoire Bénédict Acta Vet Scand Research BACKGROUND: The Dachshund is a chondrodystrophic breed of dog predisposed to premature degeneration and calcification, and subsequent herniation, of intervertebral discs (IVDs). This condition is heritable in Dachshunds and breeding candidates are screened for radiographically detectable intervertebral disc calcification (RDIDC), a feature of advanced disc degeneration and a prognostic factor for clinical disease. RDIDC scoring has been previously shown to be consistent within scorers; however, strong scorer effect (subjectivity) was also reported. The aim of this study was to estimate the within- and between-scorer agreement (repeatability and reproducibility, respectively) of computed tomography (CT) scanning and magnetic resonance imaging (MRI) for scoring IVD calcification, and to compare these modalities with radiographic scoring. RESULTS: Twenty-one Dachshund dogs were screened for IVD calcification using the three imaging modalities. Three scorers scored each case twice, independently. Repeatability was highest for radiography (95.4%), and significantly higher than for CT (90.4%) but not MRI (93.8%). Reproducibility was also highest for radiography (92.9%), but not significantly higher than for CT or MRI (89.4% and 86.4%, respectively). Overall, CT scored IVDs differently than radiography and MRI (64.8% and 62.7% agreement, respectively), while radiography and MRI scored more similarly (85.7% agreement). CONCLUSIONS: Despite high precision for radiography, previous evidence of scorer subjectivity was confirmed, which was not generally observed with CT and MRI. The increased consistency of radiography may be related to prior scorer experience with the modality and RDIDC scoring. This study does not support replacing radiography with CT or MRI to screen for heritable IVD calcification in breeding Dachshunds; however, evaluation of dog-level precision and the accuracy of each modality is recommended. BioMed Central 2018-10-13 /pmc/articles/PMC6186048/ /pubmed/30316295 http://dx.doi.org/10.1186/s13028-018-0416-2 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Rosenblatt, Alana Jayne Lappalainen, Anu Katriina James, Nina Alice Webster, Natalie Siu Ling Caraguel, Charles Grégoire Bénédict Scorer and modality agreement for the detection of intervertebral disc calcification in Dachshunds |
title | Scorer and modality agreement for the detection of intervertebral disc calcification in Dachshunds |
title_full | Scorer and modality agreement for the detection of intervertebral disc calcification in Dachshunds |
title_fullStr | Scorer and modality agreement for the detection of intervertebral disc calcification in Dachshunds |
title_full_unstemmed | Scorer and modality agreement for the detection of intervertebral disc calcification in Dachshunds |
title_short | Scorer and modality agreement for the detection of intervertebral disc calcification in Dachshunds |
title_sort | scorer and modality agreement for the detection of intervertebral disc calcification in dachshunds |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186048/ https://www.ncbi.nlm.nih.gov/pubmed/30316295 http://dx.doi.org/10.1186/s13028-018-0416-2 |
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