Cargando…
Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment
BACKGROUND: We developed a novel plasma amino acid profile-based index (API) to detect ovarian, uterine, cervical, and endometrial cancers. In this study, we aimed to evaluate whether abnormal API values could be normalized after curative treatment in patients with gynecological malignant tumors. ME...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186072/ https://www.ncbi.nlm.nih.gov/pubmed/30314462 http://dx.doi.org/10.1186/s12885-018-4875-7 |
_version_ | 1783362803647643648 |
---|---|
author | Suzuki, Yukio Tokinaga-Uchiyama, Aya Mizushima, Taichi Maruyama, Yasuyo Mogami, Tae Shikata, Nahoko Ikeda, Atsuko Yamamoto, Hiroshi Miyagi, Etsuko |
author_facet | Suzuki, Yukio Tokinaga-Uchiyama, Aya Mizushima, Taichi Maruyama, Yasuyo Mogami, Tae Shikata, Nahoko Ikeda, Atsuko Yamamoto, Hiroshi Miyagi, Etsuko |
author_sort | Suzuki, Yukio |
collection | PubMed |
description | BACKGROUND: We developed a novel plasma amino acid profile-based index (API) to detect ovarian, uterine, cervical, and endometrial cancers. In this study, we aimed to evaluate whether abnormal API values could be normalized after curative treatment in patients with gynecological malignant tumors. METHODS: Patients with gynecological cancer with abnormal API values were included in this study. Pre-operative absolute API values were compared with those after curative treatment. The normalization rates of API values in patients negative for the expression of three well-known tumor markers (SCC, CA125, and CA19–9) were also evaluated. In addition, related amino acid profiles in healthy controls and patients under pre- and post-treatment conditions were analyzed. RESULTS: Among 94 patients with abnormal pre-operative API values, the median API value was decreased from 9.52 to 2.17 after treatment (normalization rate: 88.3%). The decreased ranges were similar in patients with adenocarcinoma (6.28; 95% confidence interval [CI]: 5.43–6.95) and squamous carcinoma (7.44; 95% CI: 3.04–8.46). In 93.5% (43/46) of patients negative for tumor markers prior to operation, API values were normalized after the successful treatment. In addition, some pre-operative abnormal amino acid profiles, including Ile, Trp, and His, were reversibly normalized after treatment. CONCLUSION: The API is a promising tumor marker in gynecological malignancies for the diagnosis of remission, particularly in patients negative for general tumor markers. Further studies are needed to explore the mechanisms related to the normalization of abnormal amino acid profiles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4875-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6186072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61860722018-10-19 Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment Suzuki, Yukio Tokinaga-Uchiyama, Aya Mizushima, Taichi Maruyama, Yasuyo Mogami, Tae Shikata, Nahoko Ikeda, Atsuko Yamamoto, Hiroshi Miyagi, Etsuko BMC Cancer Research Article BACKGROUND: We developed a novel plasma amino acid profile-based index (API) to detect ovarian, uterine, cervical, and endometrial cancers. In this study, we aimed to evaluate whether abnormal API values could be normalized after curative treatment in patients with gynecological malignant tumors. METHODS: Patients with gynecological cancer with abnormal API values were included in this study. Pre-operative absolute API values were compared with those after curative treatment. The normalization rates of API values in patients negative for the expression of three well-known tumor markers (SCC, CA125, and CA19–9) were also evaluated. In addition, related amino acid profiles in healthy controls and patients under pre- and post-treatment conditions were analyzed. RESULTS: Among 94 patients with abnormal pre-operative API values, the median API value was decreased from 9.52 to 2.17 after treatment (normalization rate: 88.3%). The decreased ranges were similar in patients with adenocarcinoma (6.28; 95% confidence interval [CI]: 5.43–6.95) and squamous carcinoma (7.44; 95% CI: 3.04–8.46). In 93.5% (43/46) of patients negative for tumor markers prior to operation, API values were normalized after the successful treatment. In addition, some pre-operative abnormal amino acid profiles, including Ile, Trp, and His, were reversibly normalized after treatment. CONCLUSION: The API is a promising tumor marker in gynecological malignancies for the diagnosis of remission, particularly in patients negative for general tumor markers. Further studies are needed to explore the mechanisms related to the normalization of abnormal amino acid profiles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4875-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-12 /pmc/articles/PMC6186072/ /pubmed/30314462 http://dx.doi.org/10.1186/s12885-018-4875-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Suzuki, Yukio Tokinaga-Uchiyama, Aya Mizushima, Taichi Maruyama, Yasuyo Mogami, Tae Shikata, Nahoko Ikeda, Atsuko Yamamoto, Hiroshi Miyagi, Etsuko Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment |
title | Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment |
title_full | Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment |
title_fullStr | Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment |
title_full_unstemmed | Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment |
title_short | Normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment |
title_sort | normalization of abnormal plasma amino acid profile-based indexes in patients with gynecological malignant tumors after curative treatment |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186072/ https://www.ncbi.nlm.nih.gov/pubmed/30314462 http://dx.doi.org/10.1186/s12885-018-4875-7 |
work_keys_str_mv | AT suzukiyukio normalizationofabnormalplasmaaminoacidprofilebasedindexesinpatientswithgynecologicalmalignanttumorsaftercurativetreatment AT tokinagauchiyamaaya normalizationofabnormalplasmaaminoacidprofilebasedindexesinpatientswithgynecologicalmalignanttumorsaftercurativetreatment AT mizushimataichi normalizationofabnormalplasmaaminoacidprofilebasedindexesinpatientswithgynecologicalmalignanttumorsaftercurativetreatment AT maruyamayasuyo normalizationofabnormalplasmaaminoacidprofilebasedindexesinpatientswithgynecologicalmalignanttumorsaftercurativetreatment AT mogamitae normalizationofabnormalplasmaaminoacidprofilebasedindexesinpatientswithgynecologicalmalignanttumorsaftercurativetreatment AT shikatanahoko normalizationofabnormalplasmaaminoacidprofilebasedindexesinpatientswithgynecologicalmalignanttumorsaftercurativetreatment AT ikedaatsuko normalizationofabnormalplasmaaminoacidprofilebasedindexesinpatientswithgynecologicalmalignanttumorsaftercurativetreatment AT yamamotohiroshi normalizationofabnormalplasmaaminoacidprofilebasedindexesinpatientswithgynecologicalmalignanttumorsaftercurativetreatment AT miyagietsuko normalizationofabnormalplasmaaminoacidprofilebasedindexesinpatientswithgynecologicalmalignanttumorsaftercurativetreatment |