A case of giant panda ovarian cancer diagnosis and histopathology

BACKGROUND: Ovarian cancer is diagnosed clinically by detecting ovarian cancer-related factors and markers. Here, we report a case of giant panda ovarian tumor metastasis with a combination of clinical and histopathological diagnosis. CASE PRESENTATION: Histopathological studies revealed severe lesi...

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Autores principales: Gao, Qi, Wang, Chengdong, Li, Desheng, Zhang, Hemin, Deng, Linhua, Li, Caiwu, Chen, Zhengli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186091/
https://www.ncbi.nlm.nih.gov/pubmed/30314476
http://dx.doi.org/10.1186/s12917-018-1630-x
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author Gao, Qi
Wang, Chengdong
Li, Desheng
Zhang, Hemin
Deng, Linhua
Li, Caiwu
Chen, Zhengli
author_facet Gao, Qi
Wang, Chengdong
Li, Desheng
Zhang, Hemin
Deng, Linhua
Li, Caiwu
Chen, Zhengli
author_sort Gao, Qi
collection PubMed
description BACKGROUND: Ovarian cancer is diagnosed clinically by detecting ovarian cancer-related factors and markers. Here, we report a case of giant panda ovarian tumor metastasis with a combination of clinical and histopathological diagnosis. CASE PRESENTATION: Histopathological studies revealed severe lesions and tumor cells in the ovaries, lungs, spleen, kidneys and perianal tissue. Immunohistochemistry staining showed that the ovarian cancer markers B7-H4, CA125, and HE4 were highly expressed in the lungs, kidneys, spleen, ovaries and perianal tissue. Tumor marker tests detected significantly high levels of AFP in serum. CONCLUSION: Clinical biomarkers combined with histopathology can provide a more accurate diagnosis of ovarian cancer metastasis and identification of ovarian cancer types than either method alone. The giant panda’s death may be due to granulosa cell tumor and theca cell tumor metastasis causing multiple organ dysfunction or even failure.
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spelling pubmed-61860912018-10-19 A case of giant panda ovarian cancer diagnosis and histopathology Gao, Qi Wang, Chengdong Li, Desheng Zhang, Hemin Deng, Linhua Li, Caiwu Chen, Zhengli BMC Vet Res Case Report BACKGROUND: Ovarian cancer is diagnosed clinically by detecting ovarian cancer-related factors and markers. Here, we report a case of giant panda ovarian tumor metastasis with a combination of clinical and histopathological diagnosis. CASE PRESENTATION: Histopathological studies revealed severe lesions and tumor cells in the ovaries, lungs, spleen, kidneys and perianal tissue. Immunohistochemistry staining showed that the ovarian cancer markers B7-H4, CA125, and HE4 were highly expressed in the lungs, kidneys, spleen, ovaries and perianal tissue. Tumor marker tests detected significantly high levels of AFP in serum. CONCLUSION: Clinical biomarkers combined with histopathology can provide a more accurate diagnosis of ovarian cancer metastasis and identification of ovarian cancer types than either method alone. The giant panda’s death may be due to granulosa cell tumor and theca cell tumor metastasis causing multiple organ dysfunction or even failure. BioMed Central 2018-10-12 /pmc/articles/PMC6186091/ /pubmed/30314476 http://dx.doi.org/10.1186/s12917-018-1630-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Gao, Qi
Wang, Chengdong
Li, Desheng
Zhang, Hemin
Deng, Linhua
Li, Caiwu
Chen, Zhengli
A case of giant panda ovarian cancer diagnosis and histopathology
title A case of giant panda ovarian cancer diagnosis and histopathology
title_full A case of giant panda ovarian cancer diagnosis and histopathology
title_fullStr A case of giant panda ovarian cancer diagnosis and histopathology
title_full_unstemmed A case of giant panda ovarian cancer diagnosis and histopathology
title_short A case of giant panda ovarian cancer diagnosis and histopathology
title_sort case of giant panda ovarian cancer diagnosis and histopathology
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186091/
https://www.ncbi.nlm.nih.gov/pubmed/30314476
http://dx.doi.org/10.1186/s12917-018-1630-x
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