Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression

PURPOSE: Gene expression profiling can uncover biologic mechanisms underlying disease and is important in drug development. RNA sequencing (RNA-seq) is routinely used to assess gene expression, but costs remain high. Sample multiplexing reduces RNA-seq costs; however, multiplexed samples have lower...

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Detalles Bibliográficos
Autores principales: Stupnikov, Alexey, O’Reilly, Paul G., McInerney, Caitriona E., Roddy, Aideen C., Dunne, Philip D., Gilmore, Alan, Ellis, Hayley P., Flannery, Tom, Healy, Estelle, McIntosh, Stuart A., Savage, Kienan, Kurian, Kathreena M., Emmert-Streib, Frank, Prise, Kevin M., Salto-Tellez, Manuel, McArt, Darragh G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2018
Materias:
Original Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186166/
https://www.ncbi.nlm.nih.gov/pubmed/30324181
http://dx.doi.org/10.1200/PO.18.00014

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