Long‐Term Engraftment (16 Years) of Myoblasts in a Human Infarcted Heart

We report the case of a patient who had undergone injections of myoblasts in an infarct area 16 years before being referred for heart transplantation. The pathological examination of the explanted heart found persisting myotubes embedded in fibrosis. This finding supports the ability of myoblasts to...

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Detalles Bibliográficos
Autores principales: Crahès, Marie, Bories, Marie‐Cécile, Viquin, Jean‐Thomas, Marolleau, Jean‐Pierre, Desnos, Michel, Larghero, Jérôme, Soulat, Gilles, Bruneval, Patrick, Hagège, Albert A., Menasché, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Human Clinical Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186271/
https://www.ncbi.nlm.nih.gov/pubmed/30211981
http://dx.doi.org/10.1002/sctm.18-0017
Descripción
Sumario:We report the case of a patient who had undergone injections of myoblasts in an infarct area 16 years before being referred for heart transplantation. The pathological examination of the explanted heart found persisting myotubes embedded in fibrosis. This finding supports the ability of myoblasts to survive in harsh environments, which can make them appealing candidates for transplantation in diseases requiring supply of new myogenic cells. Stem Cells Translational Medicine 2018;7:705–708

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