An Overview of The Globozoospermia as A Multigenic Identified Syndrome

Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome bio...

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Autores principales: Modarres, Parastoo, Tavalaee, Marziyeh, Ghaedi, Kamran, Nasr-Esfahani, Mohammad Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186287/
https://www.ncbi.nlm.nih.gov/pubmed/30291685
http://dx.doi.org/10.22074/ijfs.2019.5561
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author Modarres, Parastoo
Tavalaee, Marziyeh
Ghaedi, Kamran
Nasr-Esfahani, Mohammad Hossein
author_facet Modarres, Parastoo
Tavalaee, Marziyeh
Ghaedi, Kamran
Nasr-Esfahani, Mohammad Hossein
author_sort Modarres, Parastoo
collection PubMed
description Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome biogenesis including, trans-golgi network (TGN), acroplaxome and cellular trafficking. This review aims to explain roles of related signals and molecules involved in this process and also describe how their absence in form of mutation, deletion and knockout model may lead to phe- nomenon referred to globozoospermia.
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spelling pubmed-61862872019-01-01 An Overview of The Globozoospermia as A Multigenic Identified Syndrome Modarres, Parastoo Tavalaee, Marziyeh Ghaedi, Kamran Nasr-Esfahani, Mohammad Hossein Int J Fertil Steril Review Article Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI). A variety of processes, organelles and structures are involved in acrosome biogenesis including, trans-golgi network (TGN), acroplaxome and cellular trafficking. This review aims to explain roles of related signals and molecules involved in this process and also describe how their absence in form of mutation, deletion and knockout model may lead to phe- nomenon referred to globozoospermia. Royan Institute 2019 2018-10-02 /pmc/articles/PMC6186287/ /pubmed/30291685 http://dx.doi.org/10.22074/ijfs.2019.5561 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Modarres, Parastoo
Tavalaee, Marziyeh
Ghaedi, Kamran
Nasr-Esfahani, Mohammad Hossein
An Overview of The Globozoospermia as A Multigenic Identified Syndrome
title An Overview of The Globozoospermia as A Multigenic Identified Syndrome
title_full An Overview of The Globozoospermia as A Multigenic Identified Syndrome
title_fullStr An Overview of The Globozoospermia as A Multigenic Identified Syndrome
title_full_unstemmed An Overview of The Globozoospermia as A Multigenic Identified Syndrome
title_short An Overview of The Globozoospermia as A Multigenic Identified Syndrome
title_sort overview of the globozoospermia as a multigenic identified syndrome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186287/
https://www.ncbi.nlm.nih.gov/pubmed/30291685
http://dx.doi.org/10.22074/ijfs.2019.5561
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