Cargando…

Significant Correlation between High-Risk HPV DNA in Semen and Impairment of Sperm Quality in Infertile Men

BACKGROUND: Human papillomavirus (HPV) is a DNA virus that causes sexually transmitted infections (STI). Recent reports suggest that HPV may affect sperm parameters and lead to male infertility. This study aims to evaluate the cor- relation between seminal high-risk HPV infection and impairment of s...

Descripción completa

Detalles Bibliográficos
Autores principales: Moghimi, Mansour, Zabihi-Mahmoodabadi, Somayeh, Kheirkhah-Vakilabad, Aliasghar, Kargar, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186290/
https://www.ncbi.nlm.nih.gov/pubmed/30291691
http://dx.doi.org/10.22074/ijfs.2019.5421
_version_ 1783362833041326080
author Moghimi, Mansour
Zabihi-Mahmoodabadi, Somayeh
Kheirkhah-Vakilabad, Aliasghar
Kargar, Zahra
author_facet Moghimi, Mansour
Zabihi-Mahmoodabadi, Somayeh
Kheirkhah-Vakilabad, Aliasghar
Kargar, Zahra
author_sort Moghimi, Mansour
collection PubMed
description BACKGROUND: Human papillomavirus (HPV) is a DNA virus that causes sexually transmitted infections (STI). Recent reports suggest that HPV may affect sperm parameters and lead to male infertility. This study aims to evaluate the cor- relation between seminal high-risk HPV infection and impairment of sperm quality in infertile Iranian men. MATERIALS AND METHODS: In this case-control study, we collected fresh semen samples from 70 fertile men and 70 confirmed infertile men who referred to Yazd Infertility Centre in 2015. Semen analyses were performed according to the World Health Organization (WHO) guidelines. High-risk HPV DNA was detected by real-time polymerase chain reaction (PCR). RESULTS: A total of 140 subjects participated in the current study. Among 70 confirmed infertile males, only 8 (11.43%) cases tested positive for high-risk HPV and all fertile men were HPV-negative. This data revealed a significant asso- ciation between high-risk HPV and male infertility (P=0.03). The percentage of normal sperm morphology and sperm motility rate significantly declined in men infected with HPV (P<0.001). CONCLUSION: There was a significantly higher prevalence of high-risk HPV in infertile men than fertile men. HPV infection seemed to be a risk factor for male infertility. Additional, larger studies should be conducted to confirm the impact of HPV on male infertility.
format Online
Article
Text
id pubmed-6186290
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Royan Institute
record_format MEDLINE/PubMed
spelling pubmed-61862902019-01-01 Significant Correlation between High-Risk HPV DNA in Semen and Impairment of Sperm Quality in Infertile Men Moghimi, Mansour Zabihi-Mahmoodabadi, Somayeh Kheirkhah-Vakilabad, Aliasghar Kargar, Zahra Int J Fertil Steril Original Article BACKGROUND: Human papillomavirus (HPV) is a DNA virus that causes sexually transmitted infections (STI). Recent reports suggest that HPV may affect sperm parameters and lead to male infertility. This study aims to evaluate the cor- relation between seminal high-risk HPV infection and impairment of sperm quality in infertile Iranian men. MATERIALS AND METHODS: In this case-control study, we collected fresh semen samples from 70 fertile men and 70 confirmed infertile men who referred to Yazd Infertility Centre in 2015. Semen analyses were performed according to the World Health Organization (WHO) guidelines. High-risk HPV DNA was detected by real-time polymerase chain reaction (PCR). RESULTS: A total of 140 subjects participated in the current study. Among 70 confirmed infertile males, only 8 (11.43%) cases tested positive for high-risk HPV and all fertile men were HPV-negative. This data revealed a significant asso- ciation between high-risk HPV and male infertility (P=0.03). The percentage of normal sperm morphology and sperm motility rate significantly declined in men infected with HPV (P<0.001). CONCLUSION: There was a significantly higher prevalence of high-risk HPV in infertile men than fertile men. HPV infection seemed to be a risk factor for male infertility. Additional, larger studies should be conducted to confirm the impact of HPV on male infertility. Royan Institute 2019 2018-10-02 /pmc/articles/PMC6186290/ /pubmed/30291691 http://dx.doi.org/10.22074/ijfs.2019.5421 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Moghimi, Mansour
Zabihi-Mahmoodabadi, Somayeh
Kheirkhah-Vakilabad, Aliasghar
Kargar, Zahra
Significant Correlation between High-Risk HPV DNA in Semen and Impairment of Sperm Quality in Infertile Men
title Significant Correlation between High-Risk HPV DNA in Semen and Impairment of Sperm Quality in Infertile Men
title_full Significant Correlation between High-Risk HPV DNA in Semen and Impairment of Sperm Quality in Infertile Men
title_fullStr Significant Correlation between High-Risk HPV DNA in Semen and Impairment of Sperm Quality in Infertile Men
title_full_unstemmed Significant Correlation between High-Risk HPV DNA in Semen and Impairment of Sperm Quality in Infertile Men
title_short Significant Correlation between High-Risk HPV DNA in Semen and Impairment of Sperm Quality in Infertile Men
title_sort significant correlation between high-risk hpv dna in semen and impairment of sperm quality in infertile men
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186290/
https://www.ncbi.nlm.nih.gov/pubmed/30291691
http://dx.doi.org/10.22074/ijfs.2019.5421
work_keys_str_mv AT moghimimansour significantcorrelationbetweenhighriskhpvdnainsemenandimpairmentofspermqualityininfertilemen
AT zabihimahmoodabadisomayeh significantcorrelationbetweenhighriskhpvdnainsemenandimpairmentofspermqualityininfertilemen
AT kheirkhahvakilabadaliasghar significantcorrelationbetweenhighriskhpvdnainsemenandimpairmentofspermqualityininfertilemen
AT kargarzahra significantcorrelationbetweenhighriskhpvdnainsemenandimpairmentofspermqualityininfertilemen