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The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats
Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186362/ https://www.ncbi.nlm.nih.gov/pubmed/30364022 http://dx.doi.org/10.1155/2018/5367814 |
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author | Cai, Hongcai Zhang, Guowei Yan, Zechen Shang, Xuejun |
author_facet | Cai, Hongcai Zhang, Guowei Yan, Zechen Shang, Xuejun |
author_sort | Cai, Hongcai |
collection | PubMed |
description | Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of XLQ capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of XLQ, and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-α, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-α, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with XLQ, significant reductions of prostate weights, prostate index, IL-8, TNF-α, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that XLQ can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis. |
format | Online Article Text |
id | pubmed-6186362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61863622018-10-24 The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats Cai, Hongcai Zhang, Guowei Yan, Zechen Shang, Xuejun Evid Based Complement Alternat Med Research Article Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of XLQ capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of XLQ, and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-α, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-α, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with XLQ, significant reductions of prostate weights, prostate index, IL-8, TNF-α, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that XLQ can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis. Hindawi 2018-09-30 /pmc/articles/PMC6186362/ /pubmed/30364022 http://dx.doi.org/10.1155/2018/5367814 Text en Copyright © 2018 Hongcai Cai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cai, Hongcai Zhang, Guowei Yan, Zechen Shang, Xuejun The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats |
title | The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats |
title_full | The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats |
title_fullStr | The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats |
title_full_unstemmed | The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats |
title_short | The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats |
title_sort | effect of xialiqi capsule on testosterone-induced benign prostatic hyperplasia in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186362/ https://www.ncbi.nlm.nih.gov/pubmed/30364022 http://dx.doi.org/10.1155/2018/5367814 |
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