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AB093. The effect of different strategies of vessel management on vasovasostomy

BACKGROUND: To study the effect of different strategies of vessel management on vasovasostomy. METHODS: Fifty 8-week-old male Sprague-Dawley rats were randomly divided into groups A, B, C, D and E. In group A all the vessels were preserved. In group B all vessels were ligated and cut. In group C onl...

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Autores principales: Lan, Ruzhu, Zhang, Jiayuan, Qi, Qian, Zhang, Huiping, Xiong, Chengliang, Wang, Tao, Liu, Jihong, Wang, Shaogang, Ye, Zhangqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186745/
http://dx.doi.org/10.21037/tau.2018.AB093
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author Lan, Ruzhu
Zhang, Jiayuan
Qi, Qian
Zhang, Huiping
Xiong, Chengliang
Wang, Tao
Liu, Jihong
Wang, Shaogang
Ye, Zhangqun
author_facet Lan, Ruzhu
Zhang, Jiayuan
Qi, Qian
Zhang, Huiping
Xiong, Chengliang
Wang, Tao
Liu, Jihong
Wang, Shaogang
Ye, Zhangqun
author_sort Lan, Ruzhu
collection PubMed
description BACKGROUND: To study the effect of different strategies of vessel management on vasovasostomy. METHODS: Fifty 8-week-old male Sprague-Dawley rats were randomly divided into groups A, B, C, D and E. In group A all the vessels were preserved. In group B all vessels were ligated and cut. In group C only arteries were preserved. In all the groups above end to end anastomosis were performed and contralateral testis was removed. In group D only veins were preserved. Group E is the control group with vas deferens intact. All rats’ testicles were measured the size before operations. After 4 weeks, the rats were raised with female rats with 1:1 in the same cage for 2 weeks and the number of pregnant rats were recorded. Then rats were sacrificed, dissected and testicles and vas deferens were collected and detect the patency. RESULTS: The patency rate was 90%, 80%, 90%, 80%, 100% and conception rate was 30%, 30%, 20%, 30%, 80% in groups A, B, C, D and E respectively. Preoperative testicular volume was 1.88667±0.11912, 1.176293±0.06971, 1.91651±0.1163, 1.82947±0.12312, 1.80818±0.149 cm(3) in groups A, B, C, D and E respectively and 6 weeks postoperative testicular volume was 1.21519±0.19, 1.20181±0.17, 1.27018±0.29, 1.23696±0.21, 1.78842±0.12 cm(3). Rate of testicular atrophy was 70%, 50%, 50%, 70%, 0% and rate of postoperative adhesion was 60%, 50%, 50%, 60%, 0% in groups A, B, C, D and E respectively. There was no significant difference in patency rate, conception rate, testicular atrophy and adhesion among the groups (P>0.05) while statistically significant to the control group (P<0.05). Logistic regression analysis showed postoperative adhesion increased the risk testicular atrophy. (OR =60.000000, P<0.05), while testicular atrophy was negatively correlated with pregnancy rate (OR =0.048128, P<0.05). CONCLUSIONS: Devascularization does not affect the surgical outcomes of vasovasostomy (VV). Postoperative adhesion can increase the risk of testicular atrophy after vasovasostomy, then consequently affects the rate of pregnancy. Reduction in postoperative adhesion may play a role in vasovasostomy outcomes.
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spelling pubmed-61867452018-10-26 AB093. The effect of different strategies of vessel management on vasovasostomy Lan, Ruzhu Zhang, Jiayuan Qi, Qian Zhang, Huiping Xiong, Chengliang Wang, Tao Liu, Jihong Wang, Shaogang Ye, Zhangqun Transl Androl Urol Printed Abstract BACKGROUND: To study the effect of different strategies of vessel management on vasovasostomy. METHODS: Fifty 8-week-old male Sprague-Dawley rats were randomly divided into groups A, B, C, D and E. In group A all the vessels were preserved. In group B all vessels were ligated and cut. In group C only arteries were preserved. In all the groups above end to end anastomosis were performed and contralateral testis was removed. In group D only veins were preserved. Group E is the control group with vas deferens intact. All rats’ testicles were measured the size before operations. After 4 weeks, the rats were raised with female rats with 1:1 in the same cage for 2 weeks and the number of pregnant rats were recorded. Then rats were sacrificed, dissected and testicles and vas deferens were collected and detect the patency. RESULTS: The patency rate was 90%, 80%, 90%, 80%, 100% and conception rate was 30%, 30%, 20%, 30%, 80% in groups A, B, C, D and E respectively. Preoperative testicular volume was 1.88667±0.11912, 1.176293±0.06971, 1.91651±0.1163, 1.82947±0.12312, 1.80818±0.149 cm(3) in groups A, B, C, D and E respectively and 6 weeks postoperative testicular volume was 1.21519±0.19, 1.20181±0.17, 1.27018±0.29, 1.23696±0.21, 1.78842±0.12 cm(3). Rate of testicular atrophy was 70%, 50%, 50%, 70%, 0% and rate of postoperative adhesion was 60%, 50%, 50%, 60%, 0% in groups A, B, C, D and E respectively. There was no significant difference in patency rate, conception rate, testicular atrophy and adhesion among the groups (P>0.05) while statistically significant to the control group (P<0.05). Logistic regression analysis showed postoperative adhesion increased the risk testicular atrophy. (OR =60.000000, P<0.05), while testicular atrophy was negatively correlated with pregnancy rate (OR =0.048128, P<0.05). CONCLUSIONS: Devascularization does not affect the surgical outcomes of vasovasostomy (VV). Postoperative adhesion can increase the risk of testicular atrophy after vasovasostomy, then consequently affects the rate of pregnancy. Reduction in postoperative adhesion may play a role in vasovasostomy outcomes. AME Publishing Company 2018-09 /pmc/articles/PMC6186745/ http://dx.doi.org/10.21037/tau.2018.AB093 Text en 2018 Translational Andrology and Urology. All rights reserved.
spellingShingle Printed Abstract
Lan, Ruzhu
Zhang, Jiayuan
Qi, Qian
Zhang, Huiping
Xiong, Chengliang
Wang, Tao
Liu, Jihong
Wang, Shaogang
Ye, Zhangqun
AB093. The effect of different strategies of vessel management on vasovasostomy
title AB093. The effect of different strategies of vessel management on vasovasostomy
title_full AB093. The effect of different strategies of vessel management on vasovasostomy
title_fullStr AB093. The effect of different strategies of vessel management on vasovasostomy
title_full_unstemmed AB093. The effect of different strategies of vessel management on vasovasostomy
title_short AB093. The effect of different strategies of vessel management on vasovasostomy
title_sort ab093. the effect of different strategies of vessel management on vasovasostomy
topic Printed Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186745/
http://dx.doi.org/10.21037/tau.2018.AB093
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