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Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study

BACKGROUND: Cryptosporidiosis is a major cause of childhood diarrhea in low- and middle-income countries and has been linked to impairment of child growth. This study investigated the burden of cryptosporidiosis and its impact on child growth in both a rural and an urban site in Bangladesh. METHODS:...

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Autores principales: Steiner, Kevin L, Ahmed, Shahnawaz, Gilchrist, Carol A, Burkey, Cecelia, Cook, Heather, Ma, Jennie Z, Korpe, Poonum S, Ahmed, Emtiaz, Alam, Masud, Kabir, Mamun, Tofail, Fahmida, Ahmed, Tahmeed, Haque, Rashidul, Petri, William A, Faruque, Abu S G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186860/
https://www.ncbi.nlm.nih.gov/pubmed/29897482
http://dx.doi.org/10.1093/cid/ciy310
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author Steiner, Kevin L
Ahmed, Shahnawaz
Gilchrist, Carol A
Burkey, Cecelia
Cook, Heather
Ma, Jennie Z
Korpe, Poonum S
Ahmed, Emtiaz
Alam, Masud
Kabir, Mamun
Tofail, Fahmida
Ahmed, Tahmeed
Haque, Rashidul
Petri, William A
Faruque, Abu S G
author_facet Steiner, Kevin L
Ahmed, Shahnawaz
Gilchrist, Carol A
Burkey, Cecelia
Cook, Heather
Ma, Jennie Z
Korpe, Poonum S
Ahmed, Emtiaz
Alam, Masud
Kabir, Mamun
Tofail, Fahmida
Ahmed, Tahmeed
Haque, Rashidul
Petri, William A
Faruque, Abu S G
author_sort Steiner, Kevin L
collection PubMed
description BACKGROUND: Cryptosporidiosis is a major cause of childhood diarrhea in low- and middle-income countries and has been linked to impairment of child growth. This study investigated the burden of cryptosporidiosis and its impact on child growth in both a rural and an urban site in Bangladesh. METHODS: Pregnant women in the second trimester were identified at 2 sites in Bangladesh, 1 urban and 1 rural. Their offspring were enrolled at birth into the study (urban, n = 250; rural, n = 258). For 2 years, the children were actively monitored for diarrhea and anthropometric measurements were obtained every 3 months. Stool samples were collected monthly and during diarrheal episodes with Cryptosporidium infection and causative species determined by quantitative polymerase chain reaction assays. RESULTS: Cryptosporidium infections were common at both sites and mostly subclinical. In the urban site, 161 (64%) children were infected and 65 (26%) had ≥2 infections. In the rural site, 114 (44%) were infected and 24 (9%) had multiple infections. Adjusted for potential confounders, cryptosporidiosis was associated with a significantly greater drop in the length-for-age z score (LAZ) at 24 months from LAZ at enrollment (Δ-LAZ), an effect greatest in the children with multiple episodes of cryptosporidiosis. The most common species in Mirpur was Cryptosporidium hominis, whereas Cryptosporidium meleagridis predominated in Mirzapur. CONCLUSIONS: Cryptosporidiosis is common in early childhood and associated with early growth faltering in Bangladeshi children. Predominant Cryptosporidium species differed between the 2 sites, suggesting different exposures or modes of transmission but similar consequences for child growth. CLINICAL TRIALS REGISTRATION: NCT02764918.
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spelling pubmed-61868602018-10-18 Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study Steiner, Kevin L Ahmed, Shahnawaz Gilchrist, Carol A Burkey, Cecelia Cook, Heather Ma, Jennie Z Korpe, Poonum S Ahmed, Emtiaz Alam, Masud Kabir, Mamun Tofail, Fahmida Ahmed, Tahmeed Haque, Rashidul Petri, William A Faruque, Abu S G Clin Infect Dis Articles and Commentaries BACKGROUND: Cryptosporidiosis is a major cause of childhood diarrhea in low- and middle-income countries and has been linked to impairment of child growth. This study investigated the burden of cryptosporidiosis and its impact on child growth in both a rural and an urban site in Bangladesh. METHODS: Pregnant women in the second trimester were identified at 2 sites in Bangladesh, 1 urban and 1 rural. Their offspring were enrolled at birth into the study (urban, n = 250; rural, n = 258). For 2 years, the children were actively monitored for diarrhea and anthropometric measurements were obtained every 3 months. Stool samples were collected monthly and during diarrheal episodes with Cryptosporidium infection and causative species determined by quantitative polymerase chain reaction assays. RESULTS: Cryptosporidium infections were common at both sites and mostly subclinical. In the urban site, 161 (64%) children were infected and 65 (26%) had ≥2 infections. In the rural site, 114 (44%) were infected and 24 (9%) had multiple infections. Adjusted for potential confounders, cryptosporidiosis was associated with a significantly greater drop in the length-for-age z score (LAZ) at 24 months from LAZ at enrollment (Δ-LAZ), an effect greatest in the children with multiple episodes of cryptosporidiosis. The most common species in Mirpur was Cryptosporidium hominis, whereas Cryptosporidium meleagridis predominated in Mirzapur. CONCLUSIONS: Cryptosporidiosis is common in early childhood and associated with early growth faltering in Bangladeshi children. Predominant Cryptosporidium species differed between the 2 sites, suggesting different exposures or modes of transmission but similar consequences for child growth. CLINICAL TRIALS REGISTRATION: NCT02764918. Oxford University Press 2018-11-01 2018-04-20 /pmc/articles/PMC6186860/ /pubmed/29897482 http://dx.doi.org/10.1093/cid/ciy310 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles and Commentaries
Steiner, Kevin L
Ahmed, Shahnawaz
Gilchrist, Carol A
Burkey, Cecelia
Cook, Heather
Ma, Jennie Z
Korpe, Poonum S
Ahmed, Emtiaz
Alam, Masud
Kabir, Mamun
Tofail, Fahmida
Ahmed, Tahmeed
Haque, Rashidul
Petri, William A
Faruque, Abu S G
Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study
title Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study
title_full Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study
title_fullStr Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study
title_full_unstemmed Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study
title_short Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study
title_sort species of cryptosporidia causing subclinical infection associated with growth faltering in rural and urban bangladesh: a birth cohort study
topic Articles and Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186860/
https://www.ncbi.nlm.nih.gov/pubmed/29897482
http://dx.doi.org/10.1093/cid/ciy310
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