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Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study
BACKGROUND: Cryptosporidiosis is a major cause of childhood diarrhea in low- and middle-income countries and has been linked to impairment of child growth. This study investigated the burden of cryptosporidiosis and its impact on child growth in both a rural and an urban site in Bangladesh. METHODS:...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186860/ https://www.ncbi.nlm.nih.gov/pubmed/29897482 http://dx.doi.org/10.1093/cid/ciy310 |
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author | Steiner, Kevin L Ahmed, Shahnawaz Gilchrist, Carol A Burkey, Cecelia Cook, Heather Ma, Jennie Z Korpe, Poonum S Ahmed, Emtiaz Alam, Masud Kabir, Mamun Tofail, Fahmida Ahmed, Tahmeed Haque, Rashidul Petri, William A Faruque, Abu S G |
author_facet | Steiner, Kevin L Ahmed, Shahnawaz Gilchrist, Carol A Burkey, Cecelia Cook, Heather Ma, Jennie Z Korpe, Poonum S Ahmed, Emtiaz Alam, Masud Kabir, Mamun Tofail, Fahmida Ahmed, Tahmeed Haque, Rashidul Petri, William A Faruque, Abu S G |
author_sort | Steiner, Kevin L |
collection | PubMed |
description | BACKGROUND: Cryptosporidiosis is a major cause of childhood diarrhea in low- and middle-income countries and has been linked to impairment of child growth. This study investigated the burden of cryptosporidiosis and its impact on child growth in both a rural and an urban site in Bangladesh. METHODS: Pregnant women in the second trimester were identified at 2 sites in Bangladesh, 1 urban and 1 rural. Their offspring were enrolled at birth into the study (urban, n = 250; rural, n = 258). For 2 years, the children were actively monitored for diarrhea and anthropometric measurements were obtained every 3 months. Stool samples were collected monthly and during diarrheal episodes with Cryptosporidium infection and causative species determined by quantitative polymerase chain reaction assays. RESULTS: Cryptosporidium infections were common at both sites and mostly subclinical. In the urban site, 161 (64%) children were infected and 65 (26%) had ≥2 infections. In the rural site, 114 (44%) were infected and 24 (9%) had multiple infections. Adjusted for potential confounders, cryptosporidiosis was associated with a significantly greater drop in the length-for-age z score (LAZ) at 24 months from LAZ at enrollment (Δ-LAZ), an effect greatest in the children with multiple episodes of cryptosporidiosis. The most common species in Mirpur was Cryptosporidium hominis, whereas Cryptosporidium meleagridis predominated in Mirzapur. CONCLUSIONS: Cryptosporidiosis is common in early childhood and associated with early growth faltering in Bangladeshi children. Predominant Cryptosporidium species differed between the 2 sites, suggesting different exposures or modes of transmission but similar consequences for child growth. CLINICAL TRIALS REGISTRATION: NCT02764918. |
format | Online Article Text |
id | pubmed-6186860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61868602018-10-18 Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study Steiner, Kevin L Ahmed, Shahnawaz Gilchrist, Carol A Burkey, Cecelia Cook, Heather Ma, Jennie Z Korpe, Poonum S Ahmed, Emtiaz Alam, Masud Kabir, Mamun Tofail, Fahmida Ahmed, Tahmeed Haque, Rashidul Petri, William A Faruque, Abu S G Clin Infect Dis Articles and Commentaries BACKGROUND: Cryptosporidiosis is a major cause of childhood diarrhea in low- and middle-income countries and has been linked to impairment of child growth. This study investigated the burden of cryptosporidiosis and its impact on child growth in both a rural and an urban site in Bangladesh. METHODS: Pregnant women in the second trimester were identified at 2 sites in Bangladesh, 1 urban and 1 rural. Their offspring were enrolled at birth into the study (urban, n = 250; rural, n = 258). For 2 years, the children were actively monitored for diarrhea and anthropometric measurements were obtained every 3 months. Stool samples were collected monthly and during diarrheal episodes with Cryptosporidium infection and causative species determined by quantitative polymerase chain reaction assays. RESULTS: Cryptosporidium infections were common at both sites and mostly subclinical. In the urban site, 161 (64%) children were infected and 65 (26%) had ≥2 infections. In the rural site, 114 (44%) were infected and 24 (9%) had multiple infections. Adjusted for potential confounders, cryptosporidiosis was associated with a significantly greater drop in the length-for-age z score (LAZ) at 24 months from LAZ at enrollment (Δ-LAZ), an effect greatest in the children with multiple episodes of cryptosporidiosis. The most common species in Mirpur was Cryptosporidium hominis, whereas Cryptosporidium meleagridis predominated in Mirzapur. CONCLUSIONS: Cryptosporidiosis is common in early childhood and associated with early growth faltering in Bangladeshi children. Predominant Cryptosporidium species differed between the 2 sites, suggesting different exposures or modes of transmission but similar consequences for child growth. CLINICAL TRIALS REGISTRATION: NCT02764918. Oxford University Press 2018-11-01 2018-04-20 /pmc/articles/PMC6186860/ /pubmed/29897482 http://dx.doi.org/10.1093/cid/ciy310 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles and Commentaries Steiner, Kevin L Ahmed, Shahnawaz Gilchrist, Carol A Burkey, Cecelia Cook, Heather Ma, Jennie Z Korpe, Poonum S Ahmed, Emtiaz Alam, Masud Kabir, Mamun Tofail, Fahmida Ahmed, Tahmeed Haque, Rashidul Petri, William A Faruque, Abu S G Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study |
title | Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study |
title_full | Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study |
title_fullStr | Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study |
title_full_unstemmed | Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study |
title_short | Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study |
title_sort | species of cryptosporidia causing subclinical infection associated with growth faltering in rural and urban bangladesh: a birth cohort study |
topic | Articles and Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186860/ https://www.ncbi.nlm.nih.gov/pubmed/29897482 http://dx.doi.org/10.1093/cid/ciy310 |
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