[(18)F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion

The PET ligand [(18)F]AV‐1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with TDP‐43 pathology. Here we assessed [(18)F]AV‐1451 binding in behavioral variant...

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Autores principales: Bevan‐Jones, Richard W., Cope, Thomas E., Jones, Simon P., Passamonti, Luca, Hong, Young T., Fryer, Tim, Arnold, Robert, Coles, Jonathan P., Aigbirhio, Franklin A., Patterson, Karalyn, O'Brien, John T., Rowe, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186940/
https://www.ncbi.nlm.nih.gov/pubmed/30349864
http://dx.doi.org/10.1002/acn3.631
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author Bevan‐Jones, Richard W.
Cope, Thomas E.
Jones, Simon P.
Passamonti, Luca
Hong, Young T.
Fryer, Tim
Arnold, Robert
Coles, Jonathan P.
Aigbirhio, Franklin A.
Patterson, Karalyn
O'Brien, John T.
Rowe, James B.
author_facet Bevan‐Jones, Richard W.
Cope, Thomas E.
Jones, Simon P.
Passamonti, Luca
Hong, Young T.
Fryer, Tim
Arnold, Robert
Coles, Jonathan P.
Aigbirhio, Franklin A.
Patterson, Karalyn
O'Brien, John T.
Rowe, James B.
author_sort Bevan‐Jones, Richard W.
collection PubMed
description The PET ligand [(18)F]AV‐1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with TDP‐43 pathology. Here we assessed [(18)F]AV‐1451 binding in behavioral variant frontotemporal dementia due to a hexanucleotide repeat expansion in C9orf72, characterized by TDP‐43 pathology. We show that the C9orf72 mutation increases binding in frontotemporal cortex, with a distinctive distribution of binding compared with healthy controls.
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spelling pubmed-61869402018-10-22 [(18)F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion Bevan‐Jones, Richard W. Cope, Thomas E. Jones, Simon P. Passamonti, Luca Hong, Young T. Fryer, Tim Arnold, Robert Coles, Jonathan P. Aigbirhio, Franklin A. Patterson, Karalyn O'Brien, John T. Rowe, James B. Ann Clin Transl Neurol Brief Communication The PET ligand [(18)F]AV‐1451 was developed to bind tau pathology in Alzheimer's disease, but increased binding has been shown in both genetic tauopathies and in semantic dementia, a disease strongly associated with TDP‐43 pathology. Here we assessed [(18)F]AV‐1451 binding in behavioral variant frontotemporal dementia due to a hexanucleotide repeat expansion in C9orf72, characterized by TDP‐43 pathology. We show that the C9orf72 mutation increases binding in frontotemporal cortex, with a distinctive distribution of binding compared with healthy controls. John Wiley and Sons Inc. 2018-09-14 /pmc/articles/PMC6186940/ /pubmed/30349864 http://dx.doi.org/10.1002/acn3.631 Text en © 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Bevan‐Jones, Richard W.
Cope, Thomas E.
Jones, Simon P.
Passamonti, Luca
Hong, Young T.
Fryer, Tim
Arnold, Robert
Coles, Jonathan P.
Aigbirhio, Franklin A.
Patterson, Karalyn
O'Brien, John T.
Rowe, James B.
[(18)F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion
title [(18)F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion
title_full [(18)F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion
title_fullStr [(18)F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion
title_full_unstemmed [(18)F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion
title_short [(18)F]AV‐1451 binding is increased in frontotemporal dementia due to C9orf72 expansion
title_sort [(18)f]av‐1451 binding is increased in frontotemporal dementia due to c9orf72 expansion
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186940/
https://www.ncbi.nlm.nih.gov/pubmed/30349864
http://dx.doi.org/10.1002/acn3.631
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