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ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins

Surface protein dynamics dictate synaptic connectivity and function in neuronal circuits. ASTN2, a gene disrupted by copy number variations (CNVs) in neurodevelopmental disorders, including autism spectrum, was previously shown to regulate the surface expression of ASTN1 in glial-guided neuronal mig...

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Detalles Bibliográficos
Autores principales:	Behesti, Hourinaz, Fore, Taylor R., Wu, Peter, Horn, Zachi, Leppert, Mary, Hull, Court, Hatten, Mary E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187130/ https://www.ncbi.nlm.nih.gov/pubmed/30242134 http://dx.doi.org/10.1073/pnas.1809382115

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