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Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools
Thymidylate synthase was one of the most studied enzymes due to its critical role in molecular pathogenesis of cancer. Nevertheless, many atomistic details of its chemical mechanism remain unknown or debated, thereby imposing limits on design of novel mechanism-based anticancer therapeutics. Here, w...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187185/ https://www.ncbi.nlm.nih.gov/pubmed/30249644 http://dx.doi.org/10.1073/pnas.1811059115 |