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BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation

BRCA1 is an established breast and ovarian tumor suppressor gene that encodes multiple protein products whose individual contributions to human cancer suppression are poorly understood. BRCA1-IRIS (also known as “IRIS”), an alternatively spliced BRCA1 product and a chromatin-bound replication and tr...

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Detalles Bibliográficos
Autores principales:	Li, Andrew G., Murphy, Elizabeth C., Culhane, Aedin C., Powell, Emily, Wang, Hua, Bronson, Roderick T., Von, Thanh, Giobbie-Hurder, Anita, Gelman, Rebecca S., Briggs, Kimberly J., Piwnica-Worms, Helen, Zhao, Jean J., Kung, Andrew L., Kaelin, William G., Livingston, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187201/ https://www.ncbi.nlm.nih.gov/pubmed/30254159 http://dx.doi.org/10.1073/pnas.1807112115

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