Cargando…
Circadian Rhythms and Mitochondria: Connecting the Dots
Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evidence suggests that metabolic diseases are l...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187225/ https://www.ncbi.nlm.nih.gov/pubmed/30349557 http://dx.doi.org/10.3389/fgene.2018.00452 |
_version_ | 1783362977146077184 |
---|---|
author | Sardon Puig, Laura Valera-Alberni, Miriam Cantó, Carles Pillon, Nicolas J. |
author_facet | Sardon Puig, Laura Valera-Alberni, Miriam Cantó, Carles Pillon, Nicolas J. |
author_sort | Sardon Puig, Laura |
collection | PubMed |
description | Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evidence suggests that metabolic diseases are linked to perturbed clock machinery. The circadian clock regulates many transcriptional–translational processes influencing whole cell metabolism and particularly mitochondrial activity. In this review, we survey the current literature related to cross-talks between mitochondria and the circadian clock and unravel putative molecular links. Understanding the mechanisms that link metabolism and circadian responses to transcriptional modifications will provide valuable insights toward innovative therapeutic strategies to combat the development of metabolic disease. |
format | Online Article Text |
id | pubmed-6187225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61872252018-10-22 Circadian Rhythms and Mitochondria: Connecting the Dots Sardon Puig, Laura Valera-Alberni, Miriam Cantó, Carles Pillon, Nicolas J. Front Genet Genetics Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evidence suggests that metabolic diseases are linked to perturbed clock machinery. The circadian clock regulates many transcriptional–translational processes influencing whole cell metabolism and particularly mitochondrial activity. In this review, we survey the current literature related to cross-talks between mitochondria and the circadian clock and unravel putative molecular links. Understanding the mechanisms that link metabolism and circadian responses to transcriptional modifications will provide valuable insights toward innovative therapeutic strategies to combat the development of metabolic disease. Frontiers Media S.A. 2018-10-08 /pmc/articles/PMC6187225/ /pubmed/30349557 http://dx.doi.org/10.3389/fgene.2018.00452 Text en Copyright © 2018 Sardon Puig, Valera-Alberni, Cantó and Pillon. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Sardon Puig, Laura Valera-Alberni, Miriam Cantó, Carles Pillon, Nicolas J. Circadian Rhythms and Mitochondria: Connecting the Dots |
title | Circadian Rhythms and Mitochondria: Connecting the Dots |
title_full | Circadian Rhythms and Mitochondria: Connecting the Dots |
title_fullStr | Circadian Rhythms and Mitochondria: Connecting the Dots |
title_full_unstemmed | Circadian Rhythms and Mitochondria: Connecting the Dots |
title_short | Circadian Rhythms and Mitochondria: Connecting the Dots |
title_sort | circadian rhythms and mitochondria: connecting the dots |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187225/ https://www.ncbi.nlm.nih.gov/pubmed/30349557 http://dx.doi.org/10.3389/fgene.2018.00452 |
work_keys_str_mv | AT sardonpuiglaura circadianrhythmsandmitochondriaconnectingthedots AT valeraalbernimiriam circadianrhythmsandmitochondriaconnectingthedots AT cantocarles circadianrhythmsandmitochondriaconnectingthedots AT pillonnicolasj circadianrhythmsandmitochondriaconnectingthedots |