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Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force

Micro-dosing of fine cohesive powders is the key technology in additive manufacturing and especially in high-potency active pharmaceutical ingredients (HPAPI). However, high accuracy micro-dosing (<5 mg) of fine cohesive powder is less trivial and still remains a challenge because it is difficult...

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Autores principales: Wang, Hongcheng, Zhang, Ting, Zhao, Miaomiao, Chen, Rangrang, Wu, Liqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187270/
https://www.ncbi.nlm.nih.gov/pubmed/30393349
http://dx.doi.org/10.3390/mi9020073
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author Wang, Hongcheng
Zhang, Ting
Zhao, Miaomiao
Chen, Rangrang
Wu, Liqun
author_facet Wang, Hongcheng
Zhang, Ting
Zhao, Miaomiao
Chen, Rangrang
Wu, Liqun
author_sort Wang, Hongcheng
collection PubMed
description Micro-dosing of fine cohesive powders is the key technology in additive manufacturing and especially in high-potency active pharmaceutical ingredients (HPAPI). However, high accuracy micro-dosing (<5 mg) of fine cohesive powder is less trivial and still remains a challenge because it is difficult to eliminate the aggregation phenomena caused by the strong interparticle cohesive forces (in small capillaries). This paper presents a novel micro-dose method of fine cohesive powders via a pulse inertia force system. A piezoelectric actuator is used to provide a high enough pulse inertia force for a tapered glass nozzle and drive powder particles in the nozzle to be discharged from the nozzle orifice with the help of particle self-gravity. The nozzles with outlet diameters in the range of 100–2000 µm were fabricated via a glass heating process. The α-lactose monohydrate powder is used as the micro-dosing powder. The influences of the tapered nozzle outlet diameter, amplitude of the applied pulse voltage, and angle of the nozzle axis on micro-dosing mass are researched. The minimum mean dose mass is 0.6 mg for a single pulse inertia force. The coefficient of variation of dose mass, which represents the micro-dosing stability, can be controlled below 5% when the dose mass is relatively small.
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spelling pubmed-61872702018-11-01 Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force Wang, Hongcheng Zhang, Ting Zhao, Miaomiao Chen, Rangrang Wu, Liqun Micromachines (Basel) Article Micro-dosing of fine cohesive powders is the key technology in additive manufacturing and especially in high-potency active pharmaceutical ingredients (HPAPI). However, high accuracy micro-dosing (<5 mg) of fine cohesive powder is less trivial and still remains a challenge because it is difficult to eliminate the aggregation phenomena caused by the strong interparticle cohesive forces (in small capillaries). This paper presents a novel micro-dose method of fine cohesive powders via a pulse inertia force system. A piezoelectric actuator is used to provide a high enough pulse inertia force for a tapered glass nozzle and drive powder particles in the nozzle to be discharged from the nozzle orifice with the help of particle self-gravity. The nozzles with outlet diameters in the range of 100–2000 µm were fabricated via a glass heating process. The α-lactose monohydrate powder is used as the micro-dosing powder. The influences of the tapered nozzle outlet diameter, amplitude of the applied pulse voltage, and angle of the nozzle axis on micro-dosing mass are researched. The minimum mean dose mass is 0.6 mg for a single pulse inertia force. The coefficient of variation of dose mass, which represents the micro-dosing stability, can be controlled below 5% when the dose mass is relatively small. MDPI 2018-02-07 /pmc/articles/PMC6187270/ /pubmed/30393349 http://dx.doi.org/10.3390/mi9020073 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Hongcheng
Zhang, Ting
Zhao, Miaomiao
Chen, Rangrang
Wu, Liqun
Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force
title Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force
title_full Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force
title_fullStr Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force
title_full_unstemmed Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force
title_short Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force
title_sort micro-dosing of fine cohesive powders actuated by pulse inertia force
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187270/
https://www.ncbi.nlm.nih.gov/pubmed/30393349
http://dx.doi.org/10.3390/mi9020073
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