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Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force
Micro-dosing of fine cohesive powders is the key technology in additive manufacturing and especially in high-potency active pharmaceutical ingredients (HPAPI). However, high accuracy micro-dosing (<5 mg) of fine cohesive powder is less trivial and still remains a challenge because it is difficult...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187270/ https://www.ncbi.nlm.nih.gov/pubmed/30393349 http://dx.doi.org/10.3390/mi9020073 |
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author | Wang, Hongcheng Zhang, Ting Zhao, Miaomiao Chen, Rangrang Wu, Liqun |
author_facet | Wang, Hongcheng Zhang, Ting Zhao, Miaomiao Chen, Rangrang Wu, Liqun |
author_sort | Wang, Hongcheng |
collection | PubMed |
description | Micro-dosing of fine cohesive powders is the key technology in additive manufacturing and especially in high-potency active pharmaceutical ingredients (HPAPI). However, high accuracy micro-dosing (<5 mg) of fine cohesive powder is less trivial and still remains a challenge because it is difficult to eliminate the aggregation phenomena caused by the strong interparticle cohesive forces (in small capillaries). This paper presents a novel micro-dose method of fine cohesive powders via a pulse inertia force system. A piezoelectric actuator is used to provide a high enough pulse inertia force for a tapered glass nozzle and drive powder particles in the nozzle to be discharged from the nozzle orifice with the help of particle self-gravity. The nozzles with outlet diameters in the range of 100–2000 µm were fabricated via a glass heating process. The α-lactose monohydrate powder is used as the micro-dosing powder. The influences of the tapered nozzle outlet diameter, amplitude of the applied pulse voltage, and angle of the nozzle axis on micro-dosing mass are researched. The minimum mean dose mass is 0.6 mg for a single pulse inertia force. The coefficient of variation of dose mass, which represents the micro-dosing stability, can be controlled below 5% when the dose mass is relatively small. |
format | Online Article Text |
id | pubmed-6187270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61872702018-11-01 Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force Wang, Hongcheng Zhang, Ting Zhao, Miaomiao Chen, Rangrang Wu, Liqun Micromachines (Basel) Article Micro-dosing of fine cohesive powders is the key technology in additive manufacturing and especially in high-potency active pharmaceutical ingredients (HPAPI). However, high accuracy micro-dosing (<5 mg) of fine cohesive powder is less trivial and still remains a challenge because it is difficult to eliminate the aggregation phenomena caused by the strong interparticle cohesive forces (in small capillaries). This paper presents a novel micro-dose method of fine cohesive powders via a pulse inertia force system. A piezoelectric actuator is used to provide a high enough pulse inertia force for a tapered glass nozzle and drive powder particles in the nozzle to be discharged from the nozzle orifice with the help of particle self-gravity. The nozzles with outlet diameters in the range of 100–2000 µm were fabricated via a glass heating process. The α-lactose monohydrate powder is used as the micro-dosing powder. The influences of the tapered nozzle outlet diameter, amplitude of the applied pulse voltage, and angle of the nozzle axis on micro-dosing mass are researched. The minimum mean dose mass is 0.6 mg for a single pulse inertia force. The coefficient of variation of dose mass, which represents the micro-dosing stability, can be controlled below 5% when the dose mass is relatively small. MDPI 2018-02-07 /pmc/articles/PMC6187270/ /pubmed/30393349 http://dx.doi.org/10.3390/mi9020073 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Hongcheng Zhang, Ting Zhao, Miaomiao Chen, Rangrang Wu, Liqun Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force |
title | Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force |
title_full | Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force |
title_fullStr | Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force |
title_full_unstemmed | Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force |
title_short | Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force |
title_sort | micro-dosing of fine cohesive powders actuated by pulse inertia force |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187270/ https://www.ncbi.nlm.nih.gov/pubmed/30393349 http://dx.doi.org/10.3390/mi9020073 |
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