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Assessment of Lagrangian Modeling of Particle Motion in a Spiral Microchannel for Inertial Microfluidics

Inertial microfluidics is a promising tool for a label-free particle manipulation for microfluidics technology. It can be utilized for particle separation based on size and shape, as well as focusing of particles. Prediction of particles’ trajectories is essential for the design of inertial microflu...

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Autores principales: Rasooli, Reza, Çetin, Barbaros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187282/
https://www.ncbi.nlm.nih.gov/pubmed/30424366
http://dx.doi.org/10.3390/mi9090433
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author Rasooli, Reza
Çetin, Barbaros
author_facet Rasooli, Reza
Çetin, Barbaros
author_sort Rasooli, Reza
collection PubMed
description Inertial microfluidics is a promising tool for a label-free particle manipulation for microfluidics technology. It can be utilized for particle separation based on size and shape, as well as focusing of particles. Prediction of particles’ trajectories is essential for the design of inertial microfluidic devices. At this point, numerical modeling is an important tool to understand the underlying physics and assess the performance of devices. A Monte Carlo-type computational model based on a Lagrangian discrete phase model is developed to simulate the particle trajectories in a spiral microchannel for inertial microfluidics. The continuous phase (flow field) is solved without the presence of a discrete phase (particles) using COMSOL Multi-physics. Once the flow field is obtained, the trajectory of particles is determined in the post-processing step via the COMSOL-MATLAB interface. To resemble the operation condition of the device, the random inlet position of the particles, many particles are simulated with random initial locations from the inlet of the microchannel. The applicability of different models for the inertial forces is discussed. The computational model is verified with experimental results from the literature. Different cases in a spiral channel with aspect ratios of 2.0 and 9.0 are simulated. The simulation results for the spiral channel with an aspect ratio of 9.0 are compared against the experimental data. The results reveal that despite certain limitations of our model, the current computational model satisfactorily predicts the location and the width of the focusing streams.
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spelling pubmed-61872822018-11-01 Assessment of Lagrangian Modeling of Particle Motion in a Spiral Microchannel for Inertial Microfluidics Rasooli, Reza Çetin, Barbaros Micromachines (Basel) Article Inertial microfluidics is a promising tool for a label-free particle manipulation for microfluidics technology. It can be utilized for particle separation based on size and shape, as well as focusing of particles. Prediction of particles’ trajectories is essential for the design of inertial microfluidic devices. At this point, numerical modeling is an important tool to understand the underlying physics and assess the performance of devices. A Monte Carlo-type computational model based on a Lagrangian discrete phase model is developed to simulate the particle trajectories in a spiral microchannel for inertial microfluidics. The continuous phase (flow field) is solved without the presence of a discrete phase (particles) using COMSOL Multi-physics. Once the flow field is obtained, the trajectory of particles is determined in the post-processing step via the COMSOL-MATLAB interface. To resemble the operation condition of the device, the random inlet position of the particles, many particles are simulated with random initial locations from the inlet of the microchannel. The applicability of different models for the inertial forces is discussed. The computational model is verified with experimental results from the literature. Different cases in a spiral channel with aspect ratios of 2.0 and 9.0 are simulated. The simulation results for the spiral channel with an aspect ratio of 9.0 are compared against the experimental data. The results reveal that despite certain limitations of our model, the current computational model satisfactorily predicts the location and the width of the focusing streams. MDPI 2018-08-27 /pmc/articles/PMC6187282/ /pubmed/30424366 http://dx.doi.org/10.3390/mi9090433 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rasooli, Reza
Çetin, Barbaros
Assessment of Lagrangian Modeling of Particle Motion in a Spiral Microchannel for Inertial Microfluidics
title Assessment of Lagrangian Modeling of Particle Motion in a Spiral Microchannel for Inertial Microfluidics
title_full Assessment of Lagrangian Modeling of Particle Motion in a Spiral Microchannel for Inertial Microfluidics
title_fullStr Assessment of Lagrangian Modeling of Particle Motion in a Spiral Microchannel for Inertial Microfluidics
title_full_unstemmed Assessment of Lagrangian Modeling of Particle Motion in a Spiral Microchannel for Inertial Microfluidics
title_short Assessment of Lagrangian Modeling of Particle Motion in a Spiral Microchannel for Inertial Microfluidics
title_sort assessment of lagrangian modeling of particle motion in a spiral microchannel for inertial microfluidics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187282/
https://www.ncbi.nlm.nih.gov/pubmed/30424366
http://dx.doi.org/10.3390/mi9090433
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