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On the Bipolar DC Flow Field-Effect-Transistor for Multifunctional Sample Handing in Microfluidics: A Theoretical Analysis under the Debye–Huckel Limit
We present herein a novel method of bipolar field-effect control on DC electroosmosis (DCEO) from a physical point of view, in the context of an intelligent and robust operation tool for stratified laminar streams in microscale systems. In this unique design of the DC flow field-effect-transistor (D...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187470/ https://www.ncbi.nlm.nih.gov/pubmed/30393361 http://dx.doi.org/10.3390/mi9020082 |
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author | Liu, Weiyu Wu, Qisheng Ren, Yukun Cui, Peng Yao, Bobin Li, Yanbo Hui, Meng Jiang, Tianyi Bai, Lin |
author_facet | Liu, Weiyu Wu, Qisheng Ren, Yukun Cui, Peng Yao, Bobin Li, Yanbo Hui, Meng Jiang, Tianyi Bai, Lin |
author_sort | Liu, Weiyu |
collection | PubMed |
description | We present herein a novel method of bipolar field-effect control on DC electroosmosis (DCEO) from a physical point of view, in the context of an intelligent and robust operation tool for stratified laminar streams in microscale systems. In this unique design of the DC flow field-effect-transistor (DC-FFET), a pair of face-to-face external gate terminals are imposed with opposite gate-voltage polarities. Diffuse-charge dynamics induces heteropolar Debye screening charge within the diffuse double layer adjacent to the face-to-face oppositely-polarized gates, respectively. A background electric field is applied across the source-drain terminal and forces the face-to-face counterionic charge of reversed polarities into induced-charge electroosmotic (ICEO) vortex flow in the lateral direction. The chaotic turbulence of the transverse ICEO whirlpool interacts actively with the conventional plug flow of DCEO, giving rise to twisted streamlines for simultaneous DCEO pumping and ICEO mixing of fluid samples along the channel length direction. A mathematical model in thin-layer approximation and the low-voltage limit is subsequently established to test the feasibility of the bipolar DC-FFET configuration in electrokinetic manipulation of fluids at the micrometer dimension. According to our simulation analysis, an integrated device design with two sets of side-by-side, but upside-down gate electrode pair exhibits outstanding performance in electroconvective pumping and mixing even without any externally-applied pressure difference. Moreover, a paradigm of a microdevice for fully electrokinetics-driven analyte treatment is established with an array of reversed bipolar gate-terminal pairs arranged on top of the dielectric membrane along the channel length direction, from which we can obtain almost a perfect liquid mixture by using a smaller magnitude of gate voltages for causing less detrimental effects at a small Dukhin number. Sustained by theoretical analysis, our physical demonstration on bipolar field-effect flow control for the microfluidic device of dual functionalities in simultaneous electroconvective pumping and mixing holds great potential in the development of fully-automated liquid-phase actuators in modern microfluidic systems. |
format | Online Article Text |
id | pubmed-6187470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61874702018-11-01 On the Bipolar DC Flow Field-Effect-Transistor for Multifunctional Sample Handing in Microfluidics: A Theoretical Analysis under the Debye–Huckel Limit Liu, Weiyu Wu, Qisheng Ren, Yukun Cui, Peng Yao, Bobin Li, Yanbo Hui, Meng Jiang, Tianyi Bai, Lin Micromachines (Basel) Article We present herein a novel method of bipolar field-effect control on DC electroosmosis (DCEO) from a physical point of view, in the context of an intelligent and robust operation tool for stratified laminar streams in microscale systems. In this unique design of the DC flow field-effect-transistor (DC-FFET), a pair of face-to-face external gate terminals are imposed with opposite gate-voltage polarities. Diffuse-charge dynamics induces heteropolar Debye screening charge within the diffuse double layer adjacent to the face-to-face oppositely-polarized gates, respectively. A background electric field is applied across the source-drain terminal and forces the face-to-face counterionic charge of reversed polarities into induced-charge electroosmotic (ICEO) vortex flow in the lateral direction. The chaotic turbulence of the transverse ICEO whirlpool interacts actively with the conventional plug flow of DCEO, giving rise to twisted streamlines for simultaneous DCEO pumping and ICEO mixing of fluid samples along the channel length direction. A mathematical model in thin-layer approximation and the low-voltage limit is subsequently established to test the feasibility of the bipolar DC-FFET configuration in electrokinetic manipulation of fluids at the micrometer dimension. According to our simulation analysis, an integrated device design with two sets of side-by-side, but upside-down gate electrode pair exhibits outstanding performance in electroconvective pumping and mixing even without any externally-applied pressure difference. Moreover, a paradigm of a microdevice for fully electrokinetics-driven analyte treatment is established with an array of reversed bipolar gate-terminal pairs arranged on top of the dielectric membrane along the channel length direction, from which we can obtain almost a perfect liquid mixture by using a smaller magnitude of gate voltages for causing less detrimental effects at a small Dukhin number. Sustained by theoretical analysis, our physical demonstration on bipolar field-effect flow control for the microfluidic device of dual functionalities in simultaneous electroconvective pumping and mixing holds great potential in the development of fully-automated liquid-phase actuators in modern microfluidic systems. MDPI 2018-02-16 /pmc/articles/PMC6187470/ /pubmed/30393361 http://dx.doi.org/10.3390/mi9020082 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Weiyu Wu, Qisheng Ren, Yukun Cui, Peng Yao, Bobin Li, Yanbo Hui, Meng Jiang, Tianyi Bai, Lin On the Bipolar DC Flow Field-Effect-Transistor for Multifunctional Sample Handing in Microfluidics: A Theoretical Analysis under the Debye–Huckel Limit |
title | On the Bipolar DC Flow Field-Effect-Transistor for Multifunctional Sample Handing in Microfluidics: A Theoretical Analysis under the Debye–Huckel Limit |
title_full | On the Bipolar DC Flow Field-Effect-Transistor for Multifunctional Sample Handing in Microfluidics: A Theoretical Analysis under the Debye–Huckel Limit |
title_fullStr | On the Bipolar DC Flow Field-Effect-Transistor for Multifunctional Sample Handing in Microfluidics: A Theoretical Analysis under the Debye–Huckel Limit |
title_full_unstemmed | On the Bipolar DC Flow Field-Effect-Transistor for Multifunctional Sample Handing in Microfluidics: A Theoretical Analysis under the Debye–Huckel Limit |
title_short | On the Bipolar DC Flow Field-Effect-Transistor for Multifunctional Sample Handing in Microfluidics: A Theoretical Analysis under the Debye–Huckel Limit |
title_sort | on the bipolar dc flow field-effect-transistor for multifunctional sample handing in microfluidics: a theoretical analysis under the debye–huckel limit |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187470/ https://www.ncbi.nlm.nih.gov/pubmed/30393361 http://dx.doi.org/10.3390/mi9020082 |
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