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Disposable Optical Stretcher Fabricated by Microinjection Moulding
Microinjection moulding combined with the use of removable inserts is one of the most promising manufacturing processes for microfluidic devices, such as lab-on-chip, that have the potential to revolutionize the healthcare and diagnosis systems. In this work, we have designed, fabricated and tested...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187529/ https://www.ncbi.nlm.nih.gov/pubmed/30424321 http://dx.doi.org/10.3390/mi9080388 |
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author | Trotta, Gianluca Martínez Vázquez, Rebeca Volpe, Annalisa Modica, Francesco Ancona, Antonio Fassi, Irene Osellame, Roberto |
author_facet | Trotta, Gianluca Martínez Vázquez, Rebeca Volpe, Annalisa Modica, Francesco Ancona, Antonio Fassi, Irene Osellame, Roberto |
author_sort | Trotta, Gianluca |
collection | PubMed |
description | Microinjection moulding combined with the use of removable inserts is one of the most promising manufacturing processes for microfluidic devices, such as lab-on-chip, that have the potential to revolutionize the healthcare and diagnosis systems. In this work, we have designed, fabricated and tested a compact and disposable plastic optical stretcher. To produce the mould inserts, two micro manufacturing technologies have been used. Micro electro discharge machining (µEDM) was used to reproduce the inverse of the capillary tube connection characterized by elevated aspect ratio. The high accuracy of femtosecond laser micromachining (FLM) was exploited to manufacture the insert with perfectly aligned microfluidic channels and fibre slots, facilitating the final composition of the optical manipulation device. The optical stretcher operation was tested using microbeads and red blood cells solutions. The prototype presented in this work demonstrates the feasibility of this approach, which should guarantee real mass production of ready-to-use lab-on-chip devices. |
format | Online Article Text |
id | pubmed-6187529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61875292018-11-01 Disposable Optical Stretcher Fabricated by Microinjection Moulding Trotta, Gianluca Martínez Vázquez, Rebeca Volpe, Annalisa Modica, Francesco Ancona, Antonio Fassi, Irene Osellame, Roberto Micromachines (Basel) Article Microinjection moulding combined with the use of removable inserts is one of the most promising manufacturing processes for microfluidic devices, such as lab-on-chip, that have the potential to revolutionize the healthcare and diagnosis systems. In this work, we have designed, fabricated and tested a compact and disposable plastic optical stretcher. To produce the mould inserts, two micro manufacturing technologies have been used. Micro electro discharge machining (µEDM) was used to reproduce the inverse of the capillary tube connection characterized by elevated aspect ratio. The high accuracy of femtosecond laser micromachining (FLM) was exploited to manufacture the insert with perfectly aligned microfluidic channels and fibre slots, facilitating the final composition of the optical manipulation device. The optical stretcher operation was tested using microbeads and red blood cells solutions. The prototype presented in this work demonstrates the feasibility of this approach, which should guarantee real mass production of ready-to-use lab-on-chip devices. MDPI 2018-08-04 /pmc/articles/PMC6187529/ /pubmed/30424321 http://dx.doi.org/10.3390/mi9080388 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Trotta, Gianluca Martínez Vázquez, Rebeca Volpe, Annalisa Modica, Francesco Ancona, Antonio Fassi, Irene Osellame, Roberto Disposable Optical Stretcher Fabricated by Microinjection Moulding |
title | Disposable Optical Stretcher Fabricated by Microinjection Moulding |
title_full | Disposable Optical Stretcher Fabricated by Microinjection Moulding |
title_fullStr | Disposable Optical Stretcher Fabricated by Microinjection Moulding |
title_full_unstemmed | Disposable Optical Stretcher Fabricated by Microinjection Moulding |
title_short | Disposable Optical Stretcher Fabricated by Microinjection Moulding |
title_sort | disposable optical stretcher fabricated by microinjection moulding |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187529/ https://www.ncbi.nlm.nih.gov/pubmed/30424321 http://dx.doi.org/10.3390/mi9080388 |
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