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Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications

In contrast to traditional drug administration, targeted drug delivery can prolong, localize, target and have a protected drug interaction with the diseased tissue. Drug delivery carriers, such as polymeric micelles, liposomes, dendrimers, nanotubes, and so on, are hard to scale-up, costly, and have...

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Detalles Bibliográficos
Autores principales: Li, Hui, Chen, Jing, Zhang, Jinjie, Zhang, Jingyong, Zhao, Guoru, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187547/
https://www.ncbi.nlm.nih.gov/pubmed/30424115
http://dx.doi.org/10.3390/mi9040182
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author Li, Hui
Chen, Jing
Zhang, Jinjie
Zhang, Jingyong
Zhao, Guoru
Wang, Lei
author_facet Li, Hui
Chen, Jing
Zhang, Jinjie
Zhang, Jingyong
Zhao, Guoru
Wang, Lei
author_sort Li, Hui
collection PubMed
description In contrast to traditional drug administration, targeted drug delivery can prolong, localize, target and have a protected drug interaction with the diseased tissue. Drug delivery carriers, such as polymeric micelles, liposomes, dendrimers, nanotubes, and so on, are hard to scale-up, costly, and have short shelf life. Here we show the novel fabrication and characterization of photopatternable magnetic hollow microrobots that can potentially be utilized in microfluidics and drug delivery applications. These magnetic hollowbots can be fabricated using standard ultraviolet (UV) lithography with low cost and easily accessible equipment, which results in them being easy to scale up, and inexpensive to fabricate. Contact-free actuation of freestanding magnetic hollowbots were demonstrated by using an applied 900 G external magnetic field to achieve the movement control in an aqueous environment. According to the movement clip, the average speed of the magnetic hollowbots was estimated to be 1.9 mm/s.
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spelling pubmed-61875472018-11-01 Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications Li, Hui Chen, Jing Zhang, Jinjie Zhang, Jingyong Zhao, Guoru Wang, Lei Micromachines (Basel) Communication In contrast to traditional drug administration, targeted drug delivery can prolong, localize, target and have a protected drug interaction with the diseased tissue. Drug delivery carriers, such as polymeric micelles, liposomes, dendrimers, nanotubes, and so on, are hard to scale-up, costly, and have short shelf life. Here we show the novel fabrication and characterization of photopatternable magnetic hollow microrobots that can potentially be utilized in microfluidics and drug delivery applications. These magnetic hollowbots can be fabricated using standard ultraviolet (UV) lithography with low cost and easily accessible equipment, which results in them being easy to scale up, and inexpensive to fabricate. Contact-free actuation of freestanding magnetic hollowbots were demonstrated by using an applied 900 G external magnetic field to achieve the movement control in an aqueous environment. According to the movement clip, the average speed of the magnetic hollowbots was estimated to be 1.9 mm/s. MDPI 2018-04-13 /pmc/articles/PMC6187547/ /pubmed/30424115 http://dx.doi.org/10.3390/mi9040182 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Li, Hui
Chen, Jing
Zhang, Jinjie
Zhang, Jingyong
Zhao, Guoru
Wang, Lei
Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications
title Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications
title_full Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications
title_fullStr Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications
title_full_unstemmed Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications
title_short Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications
title_sort photopatternable magnetic hollowbots by nd-fe-b nanocomposite for potential targeted drug delivery applications
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187547/
https://www.ncbi.nlm.nih.gov/pubmed/30424115
http://dx.doi.org/10.3390/mi9040182
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