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Development of a Triple-Coaxial Flow Device for Fabricating a Hydrogel Microtube and Its Application to Bioremediation

This paper demonstrates a triple-coaxial flow device to continuously produce a hydrogel microtube using a microfluidic technique. The hydrogel microtube can encapsulate a microbial suspension, while allowing the diffusion of oxygen and nutrients into the microtube and preventing microbes from passin...

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Detalles Bibliográficos
Autores principales: Fujimoto, Kazuma, Higashi, Kazuhiko, Onoe, Hiroaki, Miki, Norihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187584/
https://www.ncbi.nlm.nih.gov/pubmed/30393352
http://dx.doi.org/10.3390/mi9020076
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author Fujimoto, Kazuma
Higashi, Kazuhiko
Onoe, Hiroaki
Miki, Norihisa
author_facet Fujimoto, Kazuma
Higashi, Kazuhiko
Onoe, Hiroaki
Miki, Norihisa
author_sort Fujimoto, Kazuma
collection PubMed
description This paper demonstrates a triple-coaxial flow device to continuously produce a hydrogel microtube using a microfluidic technique. The hydrogel microtube can encapsulate a microbial suspension, while allowing the diffusion of oxygen and nutrients into the microtube and preventing microbes from passing into or out of the microtube. The microtubes also enable the collection of the microbes after task completion without contaminating the environment. In our previous study, we used a double-coaxial flow device to produce the microtubes, but continuous production was a challenge. In the present study, we developed a microfluidic device that fabricates a triple-coaxial flow to enable continuous production of the microtubes. Here, we characterize the production capacity of the microtubes along with their properties and demonstrate bioremediation using microtubes encapsulating a microbial suspension.
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spelling pubmed-61875842018-11-01 Development of a Triple-Coaxial Flow Device for Fabricating a Hydrogel Microtube and Its Application to Bioremediation Fujimoto, Kazuma Higashi, Kazuhiko Onoe, Hiroaki Miki, Norihisa Micromachines (Basel) Article This paper demonstrates a triple-coaxial flow device to continuously produce a hydrogel microtube using a microfluidic technique. The hydrogel microtube can encapsulate a microbial suspension, while allowing the diffusion of oxygen and nutrients into the microtube and preventing microbes from passing into or out of the microtube. The microtubes also enable the collection of the microbes after task completion without contaminating the environment. In our previous study, we used a double-coaxial flow device to produce the microtubes, but continuous production was a challenge. In the present study, we developed a microfluidic device that fabricates a triple-coaxial flow to enable continuous production of the microtubes. Here, we characterize the production capacity of the microtubes along with their properties and demonstrate bioremediation using microtubes encapsulating a microbial suspension. MDPI 2018-02-12 /pmc/articles/PMC6187584/ /pubmed/30393352 http://dx.doi.org/10.3390/mi9020076 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fujimoto, Kazuma
Higashi, Kazuhiko
Onoe, Hiroaki
Miki, Norihisa
Development of a Triple-Coaxial Flow Device for Fabricating a Hydrogel Microtube and Its Application to Bioremediation
title Development of a Triple-Coaxial Flow Device for Fabricating a Hydrogel Microtube and Its Application to Bioremediation
title_full Development of a Triple-Coaxial Flow Device for Fabricating a Hydrogel Microtube and Its Application to Bioremediation
title_fullStr Development of a Triple-Coaxial Flow Device for Fabricating a Hydrogel Microtube and Its Application to Bioremediation
title_full_unstemmed Development of a Triple-Coaxial Flow Device for Fabricating a Hydrogel Microtube and Its Application to Bioremediation
title_short Development of a Triple-Coaxial Flow Device for Fabricating a Hydrogel Microtube and Its Application to Bioremediation
title_sort development of a triple-coaxial flow device for fabricating a hydrogel microtube and its application to bioremediation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187584/
https://www.ncbi.nlm.nih.gov/pubmed/30393352
http://dx.doi.org/10.3390/mi9020076
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