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Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications
The development of organ-on-chip and biological scaffolds is currently requiring simpler methods for microstructure biocompatible materials in three dimensions, to fabricate structural and functional elements in biomaterials, or modify the physicochemical properties of desired substrates. Aiming at...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187701/ https://www.ncbi.nlm.nih.gov/pubmed/30424120 http://dx.doi.org/10.3390/mi9040187 |
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author | Cruz-Ramírez, Aarón Sánchez-Olvera, Raúl Zamarrón-Hernández, Diego Hautefeuille, Mathieu Cabriales, Lucia Jiménez-Díaz, Edgar Díaz-Bello, Beatriz López-Aparicio, Jehú Pérez-Calixto, Daniel Cano-Jorge, Mariel Vázquez-Victorio, Genaro |
author_facet | Cruz-Ramírez, Aarón Sánchez-Olvera, Raúl Zamarrón-Hernández, Diego Hautefeuille, Mathieu Cabriales, Lucia Jiménez-Díaz, Edgar Díaz-Bello, Beatriz López-Aparicio, Jehú Pérez-Calixto, Daniel Cano-Jorge, Mariel Vázquez-Victorio, Genaro |
author_sort | Cruz-Ramírez, Aarón |
collection | PubMed |
description | The development of organ-on-chip and biological scaffolds is currently requiring simpler methods for microstructure biocompatible materials in three dimensions, to fabricate structural and functional elements in biomaterials, or modify the physicochemical properties of desired substrates. Aiming at addressing this need, a low-power CD-DVD-Blu-ray laser pickup head was mounted on a programmable three-axis micro-displacement system in order to modify the surface of polymeric materials in a local fashion. Thanks to a specially-designed method using a strongly absorbing additive coating the materials of interest, it has been possible to establish and precisely control processes useful in microtechnology for biomedical applications. The system was upgraded with Blu-ray laser for additive manufacturing and ablation on a single platform. In this work, we present the application of these fabrication techniques to the development of biomimetic cellular culture platforms thanks to the simple integration of several features typically achieved with traditional, less cost-effective microtechnology methods in one step or through replica-molding. Our straightforward approach indeed enables great control of local laser microablation or polymerization for true on-demand biomimetic micropatterned designs in transparent polymers and hydrogels and is allowing integration of microfluidics, microelectronics, surface microstructuring, and transfer of superficial protein micropatterns on a variety of biocompatible materials. |
format | Online Article Text |
id | pubmed-6187701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61877012018-11-01 Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications Cruz-Ramírez, Aarón Sánchez-Olvera, Raúl Zamarrón-Hernández, Diego Hautefeuille, Mathieu Cabriales, Lucia Jiménez-Díaz, Edgar Díaz-Bello, Beatriz López-Aparicio, Jehú Pérez-Calixto, Daniel Cano-Jorge, Mariel Vázquez-Victorio, Genaro Micromachines (Basel) Article The development of organ-on-chip and biological scaffolds is currently requiring simpler methods for microstructure biocompatible materials in three dimensions, to fabricate structural and functional elements in biomaterials, or modify the physicochemical properties of desired substrates. Aiming at addressing this need, a low-power CD-DVD-Blu-ray laser pickup head was mounted on a programmable three-axis micro-displacement system in order to modify the surface of polymeric materials in a local fashion. Thanks to a specially-designed method using a strongly absorbing additive coating the materials of interest, it has been possible to establish and precisely control processes useful in microtechnology for biomedical applications. The system was upgraded with Blu-ray laser for additive manufacturing and ablation on a single platform. In this work, we present the application of these fabrication techniques to the development of biomimetic cellular culture platforms thanks to the simple integration of several features typically achieved with traditional, less cost-effective microtechnology methods in one step or through replica-molding. Our straightforward approach indeed enables great control of local laser microablation or polymerization for true on-demand biomimetic micropatterned designs in transparent polymers and hydrogels and is allowing integration of microfluidics, microelectronics, surface microstructuring, and transfer of superficial protein micropatterns on a variety of biocompatible materials. MDPI 2018-04-16 /pmc/articles/PMC6187701/ /pubmed/30424120 http://dx.doi.org/10.3390/mi9040187 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cruz-Ramírez, Aarón Sánchez-Olvera, Raúl Zamarrón-Hernández, Diego Hautefeuille, Mathieu Cabriales, Lucia Jiménez-Díaz, Edgar Díaz-Bello, Beatriz López-Aparicio, Jehú Pérez-Calixto, Daniel Cano-Jorge, Mariel Vázquez-Victorio, Genaro Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications |
title | Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications |
title_full | Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications |
title_fullStr | Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications |
title_full_unstemmed | Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications |
title_short | Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications |
title_sort | progress on the use of commercial digital optical disc units for low-power laser micromachining in biomedical applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187701/ https://www.ncbi.nlm.nih.gov/pubmed/30424120 http://dx.doi.org/10.3390/mi9040187 |
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