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Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life

A drug-eluting stent with rhombic-shaped drug reservoirs is proposed, aimed at providing long-term drug delivery and enhanced fatigue life. Unique rhombic-shaped reservoirs or channels on the stent struts can increase the total drug capacity and improve the stress distribution for longer fatigue lif...

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Detalles Bibliográficos
Autores principales: Hsiao, Hao-Ming, Lin, Cheng-Han, Shen, Yung-Kang, Chou, Tzu-Yun, Hsu, Yen-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187719/
https://www.ncbi.nlm.nih.gov/pubmed/30393280
http://dx.doi.org/10.3390/mi9010003
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author Hsiao, Hao-Ming
Lin, Cheng-Han
Shen, Yung-Kang
Chou, Tzu-Yun
Hsu, Yen-Yu
author_facet Hsiao, Hao-Ming
Lin, Cheng-Han
Shen, Yung-Kang
Chou, Tzu-Yun
Hsu, Yen-Yu
author_sort Hsiao, Hao-Ming
collection PubMed
description A drug-eluting stent with rhombic-shaped drug reservoirs is proposed, aimed at providing long-term drug delivery and enhanced fatigue life. Unique rhombic-shaped reservoirs or channels on the stent struts can increase the total drug capacity and improve the stress distribution for longer fatigue life, without compromising other important clinical attributes. Our rhombic-shaped channel stent increases the total drug capacity by multiple times. Its fatigue safety factor, even with the large rhombic cutouts on the stent struts, could be 50% higher than that of the conventional drug-eluting stent. A pulsed fiber-optic laser and a series of expansions and heat treatments were used to make the first prototype of our rhombic-shaped channel stent. This new concept may open up a wide variety of new treatment options and opportunities for the medical industry in the future.
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spelling pubmed-61877192018-11-01 Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life Hsiao, Hao-Ming Lin, Cheng-Han Shen, Yung-Kang Chou, Tzu-Yun Hsu, Yen-Yu Micromachines (Basel) Article A drug-eluting stent with rhombic-shaped drug reservoirs is proposed, aimed at providing long-term drug delivery and enhanced fatigue life. Unique rhombic-shaped reservoirs or channels on the stent struts can increase the total drug capacity and improve the stress distribution for longer fatigue life, without compromising other important clinical attributes. Our rhombic-shaped channel stent increases the total drug capacity by multiple times. Its fatigue safety factor, even with the large rhombic cutouts on the stent struts, could be 50% higher than that of the conventional drug-eluting stent. A pulsed fiber-optic laser and a series of expansions and heat treatments were used to make the first prototype of our rhombic-shaped channel stent. This new concept may open up a wide variety of new treatment options and opportunities for the medical industry in the future. MDPI 2017-12-24 /pmc/articles/PMC6187719/ /pubmed/30393280 http://dx.doi.org/10.3390/mi9010003 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsiao, Hao-Ming
Lin, Cheng-Han
Shen, Yung-Kang
Chou, Tzu-Yun
Hsu, Yen-Yu
Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life
title Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life
title_full Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life
title_fullStr Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life
title_full_unstemmed Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life
title_short Rhombic-Shaped Channel Stent with Enhanced Drug Capacity and Fatigue Life
title_sort rhombic-shaped channel stent with enhanced drug capacity and fatigue life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187719/
https://www.ncbi.nlm.nih.gov/pubmed/30393280
http://dx.doi.org/10.3390/mi9010003
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