Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer

Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of...

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Autores principales: Park, Jong-Lyul, Kim, Seon-Kyu, Kim, Jeong-Hwan, Yun, Seok Joong, Kim, Wun-Jae, Kim, Won Tae, Jeong, Pildu, Kang, Ho Won, Kim, Seon-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Gastrointestinal Intervention 2018
Materias:
Clinical Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187813/
https://www.ncbi.nlm.nih.gov/pubmed/30309206
http://dx.doi.org/10.5808/GI.2018.16.3.71
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author Park, Jong-Lyul
Kim, Seon-Kyu
Kim, Jeong-Hwan
Yun, Seok Joong
Kim, Wun-Jae
Kim, Won Tae
Jeong, Pildu
Kang, Ho Won
Kim, Seon-Young
author_facet Park, Jong-Lyul
Kim, Seon-Kyu
Kim, Jeong-Hwan
Yun, Seok Joong
Kim, Wun-Jae
Kim, Won Tae
Jeong, Pildu
Kang, Ho Won
Kim, Seon-Young
author_sort Park, Jong-Lyul
collection PubMed
description Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.
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spelling pubmed-61878132018-10-17 Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer Park, Jong-Lyul Kim, Seon-Kyu Kim, Jeong-Hwan Yun, Seok Joong Kim, Wun-Jae Kim, Won Tae Jeong, Pildu Kang, Ho Won Kim, Seon-Young Genomics Inform Clinical Genomics Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC. Society of Gastrointestinal Intervention 2018-09 2018-09-30 /pmc/articles/PMC6187813/ /pubmed/30309206 http://dx.doi.org/10.5808/GI.2018.16.3.71 Text en Copyright © 2018 by the Korea Genome Organization It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Clinical Genomics
Park, Jong-Lyul
Kim, Seon-Kyu
Kim, Jeong-Hwan
Yun, Seok Joong
Kim, Wun-Jae
Kim, Won Tae
Jeong, Pildu
Kang, Ho Won
Kim, Seon-Young
Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
title Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
title_full Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
title_fullStr Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
title_full_unstemmed Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
title_short Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
title_sort generation of whole-genome sequencing data for comparing primary and castration-resistant prostate cancer
topic Clinical Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187813/
https://www.ncbi.nlm.nih.gov/pubmed/30309206
http://dx.doi.org/10.5808/GI.2018.16.3.71
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