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Optic Nerve Stimulation System with Adaptive Wireless Powering and Data Telemetry †

To treat retinal degenerative diseases, a transcorneal electrical stimulation-based system is proposed, which consists of an eye implant and an external component. The eye implant is wirelessly powered and controlled by the external component to generate the required bi-polar current pattern for tra...

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Autores principales: Li, Xing, Lu, Yan, Meng, Xiaodong, Tsui, Chi-Ying, Ki, Wing-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187914/
https://www.ncbi.nlm.nih.gov/pubmed/30400557
http://dx.doi.org/10.3390/mi8120368
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author Li, Xing
Lu, Yan
Meng, Xiaodong
Tsui, Chi-Ying
Ki, Wing-Hung
author_facet Li, Xing
Lu, Yan
Meng, Xiaodong
Tsui, Chi-Ying
Ki, Wing-Hung
author_sort Li, Xing
collection PubMed
description To treat retinal degenerative diseases, a transcorneal electrical stimulation-based system is proposed, which consists of an eye implant and an external component. The eye implant is wirelessly powered and controlled by the external component to generate the required bi-polar current pattern for transcorneal stimulation with an amplitude range of 5 μA to 320 μA, a frequency range of 10 Hz to 160 Hz and a duty ratio range of 2.5% to 20%. Power delivery control includes power boosting in preparation for stimulation, and normal power regulation that adapts to both coupling and load variations. Only one pair of coils is used for both the power link and the bi-directional data link. Except for the secondary coil, the eye implant is fully integrated on chip and is fabricated using UMC (United Microelectronics Corporation, Hsinchu, Taiwan) 0.13 μm complementary metal-oxide-semiconductor (CMOS) process with a size of 1.5 mm × 1.5 mm. The secondary coil is fabricated on a printed circuit board (PCB) with a diameter of only 4.4 mm. After coating with biocompatible silicone, the whole implant has dimensions of 6 mm in diameter with a thickness of less than 1 mm. The whole device can be put onto the sclera and beneath the eye’s conjunctiva. System functionality and electrical performance are demonstrated with measurement results.
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spelling pubmed-61879142018-11-01 Optic Nerve Stimulation System with Adaptive Wireless Powering and Data Telemetry † Li, Xing Lu, Yan Meng, Xiaodong Tsui, Chi-Ying Ki, Wing-Hung Micromachines (Basel) Article To treat retinal degenerative diseases, a transcorneal electrical stimulation-based system is proposed, which consists of an eye implant and an external component. The eye implant is wirelessly powered and controlled by the external component to generate the required bi-polar current pattern for transcorneal stimulation with an amplitude range of 5 μA to 320 μA, a frequency range of 10 Hz to 160 Hz and a duty ratio range of 2.5% to 20%. Power delivery control includes power boosting in preparation for stimulation, and normal power regulation that adapts to both coupling and load variations. Only one pair of coils is used for both the power link and the bi-directional data link. Except for the secondary coil, the eye implant is fully integrated on chip and is fabricated using UMC (United Microelectronics Corporation, Hsinchu, Taiwan) 0.13 μm complementary metal-oxide-semiconductor (CMOS) process with a size of 1.5 mm × 1.5 mm. The secondary coil is fabricated on a printed circuit board (PCB) with a diameter of only 4.4 mm. After coating with biocompatible silicone, the whole implant has dimensions of 6 mm in diameter with a thickness of less than 1 mm. The whole device can be put onto the sclera and beneath the eye’s conjunctiva. System functionality and electrical performance are demonstrated with measurement results. MDPI 2017-12-20 /pmc/articles/PMC6187914/ /pubmed/30400557 http://dx.doi.org/10.3390/mi8120368 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Xing
Lu, Yan
Meng, Xiaodong
Tsui, Chi-Ying
Ki, Wing-Hung
Optic Nerve Stimulation System with Adaptive Wireless Powering and Data Telemetry †
title Optic Nerve Stimulation System with Adaptive Wireless Powering and Data Telemetry †
title_full Optic Nerve Stimulation System with Adaptive Wireless Powering and Data Telemetry †
title_fullStr Optic Nerve Stimulation System with Adaptive Wireless Powering and Data Telemetry †
title_full_unstemmed Optic Nerve Stimulation System with Adaptive Wireless Powering and Data Telemetry †
title_short Optic Nerve Stimulation System with Adaptive Wireless Powering and Data Telemetry †
title_sort optic nerve stimulation system with adaptive wireless powering and data telemetry †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187914/
https://www.ncbi.nlm.nih.gov/pubmed/30400557
http://dx.doi.org/10.3390/mi8120368
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