Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: unique surface properties underlying alternative pathway activation and instant opsonization

BACKGROUND: It has been proposed that many hypersensitivity reactions to nanopharmaceuticals represent complement (C)-activation-related pseudoallergy (CARPA), and that pigs provide a sensitive animal model to study the phenomenon. However, a recent study suggested that pulmonary hypertension, the p...

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Detalles Bibliográficos
Autores principales: Mészáros, Tamás, Kozma, Gergely Tibor, Shimizu, Taro, Miyahara, Koga, Turjeman, Keren, Ishida, Tatsuhiro, Barenholz, Yechezkel, Urbanics, Rudolf, Szebeni, János
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187999/
https://www.ncbi.nlm.nih.gov/pubmed/30349254
http://dx.doi.org/10.2147/IJN.S161369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187999/
https://www.ncbi.nlm.nih.gov/pubmed/30349254
http://dx.doi.org/10.2147/IJN.S161369

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