Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo

BACKGROUND: Our study aimed to explore the effects of PPIs on reversing multidrug resistance (MDR) to chemotherapy in gastric cancer by inhibiting the expression of V-ATPases and the PI3K/Akt/mTOR/HIF-1α signal pathway. METHODS: The gastric cancer cell lines SGC7901 and the multidrug resistance cell...

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Detalles Bibliográficos
Autores principales: Chen, Min, Lu, Jian, Wei, Wei, Lv, Ying, Zhang, Xiaoqi, Yao, Yuling, Wang, Lei, Ling, Tingsheng, Zou, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188003/
https://www.ncbi.nlm.nih.gov/pubmed/30349304
http://dx.doi.org/10.2147/OTT.S161198

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