Functional characterization of phospholipase C-γ(2) mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder

Depending on its occurrence in the germline or somatic context, a single point mutation, S707Y, of phospholipase C-γ(2) (PLCγ(2)) gives rise to two distinct human disease states: acquired resistance of chronic lymphocytic leukemia cells (CLL) to inhibitors of Brutons´s tyrosine kinase (Btk) and domi...

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Detalles Bibliográficos
Autores principales: Walliser, Claudia, Wist, Martin, Hermkes, Elisabeth, Zhou, Yuan, Schade, Anja, Haas, Jennifer, Deinzer, Julia, Désiré, Laurent, Li, Shawn S.C., Stilgenbauer, Stephan, Milner, Joshua D., Gierschik, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188132/
https://www.ncbi.nlm.nih.gov/pubmed/30344948
http://dx.doi.org/10.18632/oncotarget.26173

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